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Developmental Biology
BIO 464-01

Instructor: Dennis R. LaJeunesse, Ph.D.
Text: Developmental Biology, Scott Gilbert
Time and place: Room 351 Eberhart, Mon/Wed/Fri 10-10:50
Labor

Course objectives: The idea of this course is to introduce the student to the following concepts:

1.) Molecular basis of developmental processes such as tissue interactions and organogenesis
2.) Genetic, cellular and, environmental factors involved in development.
3.) The experimental principles used to determine the molecular and genetic basis of development.

Grading: There will be four exams (1 lab exam, 3 in class exams) that are worth 50% of the final grade, 3 presentations that will be worth 25%, and class participation will be worth 25%.

Materials: for the lab you will need a spiral notebook and paper

Weekly schedule:

Week 1:
1/14 Class 1: Introduction
Readings: Chapter 1
1/15 Lab 1: Introduction to the lab/microscopes
1/16 **Class 2: -- no class**

Week 2:
1/21 Class 3: Life Cycles
Readings: Chapter 2
1/22 Lab 2: Drosophila development and oogenesis
1/23 Class 4: Lifecycles continued, discussion of website articles --
http://www.devbio.com/ch02.html

Week 3:
1/28 Class 5: Cell adhesion and Principles of Experimental Embryology
Readings: Chapter 3
website articles: http://www.devbio.com/ch03.html
sections 3.7, 3.8, 3.9
1/29 Lab 3: Sponges and cell adhesion
1/30 Class 6: Continuation and Discussion of cell adhesion in development
Readings: papers

Week 4:
2/4 Class 7: Genetics and Development
Readings: Chapter 4,5
2/5 Lab 4: Drosophila embryogenesis
2/6 Class 8: Genetics and Development continued

Week 5:
2/11 Class 9: Student Presentations
2/12 Lab 5: Fixation of Drosophila embryos
2/13 Class 10: Student presentations/review

Week 6:
2/18 Class 11: Cell-cell communication
Reading: Chapter 6
2/19 Lab 6: Drosophila cuticle preperation
2/20 Class 12: Exam 1

Week 7:
2/25 Class 13: Sex-determination
Reading: Chapter 17
2/26 Lab 7: Drosophila cuticle analysis
2/27 Class 14: Oogenesis and Spermatogenesis
Reading: Chapter 19

Week 8:
3/4 Class 15: Fertilization
Readings: Chapter 7
3/5 ** Lab 8: No class **
3/6 ** Class 16: No class**

-- Spring break --

Week 9:
3/18 Class 17: Drosophila Axis formation
Readings: Chapter 9
3/19 Lab 9: Drosophila antibody staining
3/20 Class 18: Amphibian Axis formation
Readings: Chapter 10,11
Week 10:
3/25 Class 19: Student Presentations
3/26 Lab 10: Imaginal discs dissection lab
3/27 Class 20: Student Presentations/review

Week 11:
4/1 Class 21: Exam II
4/2 Lab 11: Imaginal discs culture lab
4/3 Class 22: Metamorphosis, regeneration and aging
Reading: Chapter 18

Week 12:
4/8 Class 23: Sonic hedgehog and development
4/9 Lab 12: Frog development lab
4/10 Class 24: Drosophila eye development
Reading: chapter 6, pg. 156-157, paper and website http://www.devbio.com/ch6.html section 6.5

Week 13:
4/15 Class 25: Eye development: vertebrate
Readings: Chapter 12
Website: http://www.devbio.com/ch12.html sections 12.8, 12.9
4/16 Lab 13: Frog development lab
4/17 Class 26: Limb development
Readings: Chapter 14

Week 14:
4/22 Class 27: Mammalian kidney development
Readings: Chapter 460-466, paper
4/23 Lab 14: lab presentations
4/25 Class 28: Student Presentations

Week 15
4/29 Class 29: Student Presentations review
4/30 Lab 15: Lab Exam
5/1 Class 30: Exam III