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2013
89. "Semisynthesis, Cytotoxicity, Antiviral Activity, and Drug Interaction Liability of 7-O-Methylated Analogues of Flavonolignans from Milk Thistle."
Hanan S. Althagafy, Tyler N. Graf, Arlene A. Sy-Cordero, Brandon T. Gufford, Mary F. Paine, Jessica Wagoner, Stephen J. Polyak, Mitchell P. Croatt, and Nicholas H. Oberlies
Bioorganic & Medicinal Chemistry, 2013, 21, 3919-3926.
doi: 10.1016/j.bmc.2013.04.017
88. "HiFSA Fingerprinting Applied to Isomers with near-Identical NMR Spectra: The Silybin/Isosilybin Case."
José G. Napolitano, David C. Lankin, Tyler N. Graf, J. Brent Friesen, Shao-Nong Chen, James B. McAlpine, Nicholas H. Oberlies, and Guido F. Pauli
Journal of Organic Chemistry, 2013, 78, 2827-2839.
doi: 10.1021/jo302720h
87. "Benzoquinones and Terphenyl Compounds as Phosphodiesterase-4B Inhibitors from a Fungus of the Order Chaetothyriales (MSX 47445)."
Tamam El-Elimat, Mario Figueroa, Huzefa A. Raja, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Cynthia S. Day, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Natural Products, 2013, 76, 382-387.
doi: 10.1021/np300749w
86. "Silymarin for HCV Infection."
Stephen J. Polyak, Nicholas H. Oberlies, Eve-Isabelle Pécheur, Harel Dahari, Peter Ferenci, and Jean-Michel Pawlotsky
Antiviral Therapy, 2013, 18, 141-147.
doi: 10.3851/IMP2402
85. "Interaction of Silymarin Flavonolignans with Organic Anion-Transporting Polypeptides."
Kathleen Köck, Ying Xie, Roy L. Hawke, Nicholas H. Oberlies, and Kim L. R. Brouwer
Drug Metabolism and Disposition, 2013, 41, 958-965.
doi: 10.1124/dmd.112.048272
84. "Sarothrin from Alkanna Orientalis Is an Antimicrobial Agent and Efflux Pump Inhibitor."
Jessica R. Bame, Tyler N. Graf, Hiyas A. Junio, R. Owen Bussey, Scott A. Jarmusch, Tamam El-Elimat, Joseph O. Falkinham, Nicholas H. Oberlies, Richard A. Cech, and Nadja B. Cech
Planta Medica, 2013, 79, 327-329.
doi: 10.1055/s-0032-1328259
83. "Enhanced Bioactivity of Silybin B Methylation Products."
Arlene A. Sy-Cordero, Tyler N. Graf, Scott P. Runyon, Mansukh C. Wani, David J. Kroll, Rajesh Agarwal, Scott J. Brantley, Mary F. Paine, Stephen J. Polyak, and Nicholas H. Oberlies
Bioorganic & Medicinal Chemistry, 2013, 21, 742-747.
doi: 10.1016/j.bmc.2012.11.035
82. "Freshwater Ascomycetes: Minutisphaera (Dothideomycetes) revisited, including one new species from Japan."
Huzefa Raja, Kazuaki Tanaka, Kazuyuki Hirayama, Akira Hoshimoto, Nicholas H. Oberlies, Mario Figueroa, Andrew N. Miller, Steven E. Zelski, and Carol A. Shearer.
Mycologia In press, accepted 12/19/12.
81. "Freshwater Ascomycetes: Lindgomyces angustiascus, (Lindgomycetaceae, Pleosporales, Dothideomycetes), a new species occurring on submerged wood from the USA."
Huzefa Raja, Nicholas H. Oberlies, Tamama El Elimat, Andrew N. Miller, Steve Zelski, and Carol A. Shearer.
Mycoscience In press, published online 04/28/2013.
doi: 10.1016/j.myc.2012.12.004
2012
80. "Absolute Configuration of Isosilybin a by X-Ray Crystallography of the Heavy Atom Analogue 7-(4-Bromobenzoyl)Isosilybin A."
Arlene A. Sy-Cordero, Cynthia S. Day, and Nicholas H. Oberlies
Journal of Natural Products, 2012, 75, 1879-1881.
doi: 10.1021/np3005369
79. "Cytotoxic Epipolythiodioxopiperazine Alkaloids from Filamentous Fungi of the Bionectriaceae."
Mario Figueroa, Tyler N. Graf, Sloan Ayers, Audrey F. Adcock, David J. Kroll, Jilai Yang, Steven M. Swanson, Ulyana Munoz-Acuna, Esperanza J. Carcache de Blanco, Rajesh Agrawal, Mansukh C. Wani, Blaise A. Darveaux, Cedric J. Pearce, and Nicholas H. Oberlies.
Journal of Antibiotics, 2012, 65, 559-564.
PMID: 22968289; doi: 10.1038/ja.2012.69
78. "Revisiting the Enniatins: A Review of Their Isolation, Biosynthesis, Structure Determination and Biological Activities."
Arlene A. Sy-Cordero, Cedric J. Pearce, and Nicholas H. Oberlies.
Journal of Antibiotics, 2012, 65, 541-549.
PMID: 22990381; doi: 10.1038/ja.2012.71
77. "Use of the Hollow Fiber Assay for the Discovery of Novel Anticancer Agents from Fungi."
Cedric J. Pearce, Daniel D. Lantvit, Qi Shen, David Jarjoura, Xiaoli Zhang, Nicholas H. Oberlies, David J. Kroll, Mansukh C. Wani, Jimmy Orjala, Djaja D. Soejarto, Norman R. Farnsworth, Esperanza J. Carcache Blanco, James R. Fuchs, A. Douglas Kinghorn, and Steven M. Swanson.
Methods in Molecular Biology 2012, 944, 267-277.
PMID: 23065624; doi: 10.1007/978-1-62703-122-6_20
76. "Mechanisms Underlying Food–Drug Interactions: Inhibition of Intestinal Metabolism and Transport."
Christina S. Won, Nicholas H. Oberlies, and Mary F. Paine
Pharmacology & Therapeutics, 2012, 136, 186-201.
PMID: 22884524; PMCID: PMC3466398; doi: 10.1016/j.pharmthera.2012.08.001
75. "Angiopreventive Efficacy of Pure Flavonolignans from Milk Thistle Extract against Prostate Cancer: Targeting VEGF-VEGFR Signaling."
Gagan Deep, Subhash C. Gangar, Subapriya Rajamanickam, Komal Raina, Mallikarjuna Gu, Chapla Agarwal, Nicholas H. Oberlies, and Rajesh Agarwal
PLoS One, 2012, 7, e34630.
PMID: 22514647; PMCID: PMC3326063; doi: 10.1371/journal.pone.0034630
74. "Peptaibols from Two Unidentified Fungi of the Order Hypocreales with Cytotoxic, Antibiotic, and Anthelmintic Activities."
Sloan Ayers, Brandie M. Ehrmann, Audrey F. Adcock, David J. Kroll, Esperanza J. Carcache de Blanco, Qi Shen, Steven M. Swanson, Joseph O. Falkinham, Mansukh C. Wani, Sheila M. Mitchell, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Peptide Science, 2012, 18, 500-510.
PMID: 22744757; PMCID: PMC3494480; doi: 10.1002/psc.2425
73. "Chemical Diversity of Metabolites from Fungi, Cyanobacteria, and Plants Relative to FDA-Approved Anticancer Agents."
Tamam El-Elimat, Xiaoli Zhang, David Jarjoura, Franklin J. Moy, Jimmy Orjala, A. Douglas Kinghorn, Cedric J. Pearce, and Nicholas H. Oberlies
ACS Medicinal Chemistry Letters, 2012, 3, 645-649.
PMID: 22993669; PMCID: PMC3443637; doi: 10.1021/ml300105s
72. "Effects of (5z)-7-Oxozeaenol on MDA-MB-231 Breast Cancer Cells."
Ulyana Muñoz Acuña, Jennifer Wittwer, Sloan Ayers, Cedric J. Pearce, Nicholas H. Oberlies, and Esperanza J. Carcache de Blanco
Anticancer Research, 2012, 32, 2415-2421.
PMID: 22753698; http://ar.iiarjournals.org/content/32/7/2415.abstract
71. "Effects of (5z)-7-Oxozeaenol on the Oxidative Pathway of Cancer Cells."
Ulyana Muñoz Acuña, Jennifer Wittwer, Sloan Ayers, Cedric J. Pearce, Nicholas H. Oberlies, and Esperanza J. Carcache de Blanco
Anticancer Research, 2012, 32, 2665-2671.
PMID: 22753724; http://ar.iiarjournals.org/content/32/7/2665.abstract
70. "Cytotoxic Xanthone-Anthraquinone Heterodimers from an Unidentified Fungus of the Order Hypocreales (MSX 17022)."
Sloan Ayers, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Qi Shen, Steven M. Swanson, Susan Matthew, Esperanza J. Carcache de Blanco, Mansukh C. Wani, Blaise A. Darveaux, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Antibiotics, 2012, 65, 3-8.
PMID: 22068158; doi: 10.1038/ja.2011.95
2011
69. "Thielavin B Methyl Ester: A Cytotoxic Benzoate Trimer from an Unidentified Fungus (MSX 55526) from the Order Sordariales."
Sloan Ayers, Brandie M. Ehrmann, Audrey F. Adcock, David J. Kroll, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies
Tetrahedron Letters, 2011, 52, 5733-5735.
doi: 10.1016/j.tetlet.2011.08.125
68. "Differential in Vitro Effects of Intravenous Versus Oral Formulations of Silibinin on the HCV Life Cycle and Inflammation."
Jessica Wagoner, Chihiro Morishima, Tyler N. Graf, Nicholas H. Oberlies, Elodie Teissier, Eve-Isabelle Pécheur, John E. Tavis, and Stephen J. Polyak
PLoS One, 2011, 6, e16464.
PMID:21297992; PMC3030583; doi: 10.1371/journal.pone.0016464
67. "Resorcylic Acid Lactones with Cytotoxic and NF-kB Inhibitory Activities and Their Structure-Activity Relationships."
Sloan Ayers, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Susan Matthew, Esperanza J. Carcache de Blanco, Qi Shen, Steven M. Swanson, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Natural Products, 2011, 74, 1126-1131.
PMID:21513293; PMCID: PMC3111092; doi: 10.1021/np200062x
66. "Isolation and Identification of Intestinal CYP3A Inhibitors from Cranberry (Vaccinium macrocarpon) Using Human Intestinal Microsomes."
Eunkyung Kim, Arlene Sy-Cordero, Tyler N. Graf, Scott J. Brantley, Mary F. Paine, and Nicholas H. Oberlies
Planta Medica, 2011, 77, 265-270.
PMID:20717876; PMCID: PMC3023844; doi: 10.1055/s-0030-1250259
65. "Synergy-Directed Fractionation of Botanical Medicines: A Case Study with Goldenseal (Hydrastis canadensis)."
Hiyas A. Junio, Arlene A. Sy-Cordero, Keivan A. Ettefagh, Johnna T. Burns, Kathryn T. Micko, Tyler N. Graf, Scott J. Richter, Robert E. Cannon, Nicholas H. Oberlies, and and Nadja B. Cech
Journal of Natural Products, 2011, 74, 1621-1629.
PMID:21661731; PMCID: PMC3142294; doi: 10.1021/np200336g
64. "Obionin B: An O-Pyranonaphthoquinone Decaketide from an Unidentified Fungus (MSX 63619) from the Order Pleosporales."
Sloan Ayers, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Qi Shen, Steven M. Swanson, Mansukh C. Wani, Blaise A. Darveaux, Cedric J. Pearce, and Nicholas H. Oberlies Tetrahedron
Letters, 2011, 52, 5128-5230.
PMID:22025810; PMCID: PMC3183506; doi: 10.1016/j.tetlet.2011.07.102
63. "Cyclodepsipeptides, Sesquiterpenoids, and Other Cytotoxic Metabolites from the Filamentous Fungus Trichothecium sp. (MSX 51320)."
Arlene A. Sy-Cordero, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Qi Shen, Steven M. Swanson, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Natural Products, 2011, 74, 2137-2142.
PMID:21978324; doi: 10.1021/np2004243
"Correction to Cyclodepsipeptides, Sesquiterpenoids, and Other Cytotoxic Metabolites from the Filamentous Fungus Trichothecium sp. (MSX 51320)."
Arlene A. Sy-Cordero, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Qi Shen, Steven M. Swanson, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Natural Products, 2012, 75, 307-307.
doi: 10.1021/np3000766
62. "Fingolimod (FTY720): A Recently Approved Multiple Sclerosis Drug Based on a Fungal Secondary Metabolite."
Cherilyn R. Strader, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Natural Products, 2011, 74, 900-907.
PMID:21456524; doi: 10.1021/np2000528
61. "Romidepsin (Istodax, NSC 630176, FR901228, FK228, Depsipeptide): A Natural Product Recently Approved for Cutaneous T-Cell Lymphoma."
Karen M. VanderMolen, William McCulloch, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Antibiotics, 2011, 64, 525-531.
PMID: 21587264; PMCID: PMC3163831; doi: 10.1038/ja.2011.35
2010
60. "The Warfarin-Cranberry Juice Interaction Revisited: A Systematic in Vitro-in Vivo Evaluation."
Ngoc Ngo, Scott J. Brantley, Daniel R. Carrizosa, Angela D. M. Kashuba, E. Claire Dees, David J. Kroll, Nicholas H. Oberlies, and Mary F. Paine
Journal of Experimental Pharmacology, 2010, 2, 83-91.
PMID:20865058; PMCID: PMC2943398; doi: 10.2147/JEP.S11719
59. "Colchicinoids from Colchicum Crocifolium Boiss. (Colchicaceae)."
Feras Q. Alali, Ahmad A. Gharaibeh, Abdullah Ghawanmeh, Khaled Tawaha, Amjad Qandil, Jason P. Burgess, Arlene Sy, Yuka Nakanishi, David J. Kroll, and Nicholas H. Oberlies
Natural Product Research, 2010, 24, 152-159.
PMID:20077308; doi: 10.1080/14786410902941097
58. "A Randomized, Controlled, Double-Blind, Pilot Study of Milk Thistle for the Treatment of Hepatotoxicity in Childhood Acute Lymphoblastic Leukemia (ALL)."
Elena J. Ladas, David J. Kroll, Nicholas H. Oberlies, Bin Cheng, Deborah H. Ndao, Susan R. Rheingold, and Kara M. Kelly
Cancer, 2010, 116, 506-513.
PMID: 20014183; doi: 10.1002/cncr.24723
57. "Dereplication of Macrocyclic Trichothecenes from Extracts of Filamentous Fungi through UV and NMR Profiles."
Arlene A. Sy-Cordero, Tyler N. Graf, Mansukh C. Wani, David J. Kroll, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Antibiotics, 2010, 63, 539-544.
PMID:20648023; PMCID: PMC2946446; doi: 10.1038/ja.2010.77
56. "Multiple Effects of Silymarin on the Hepatitis C Virus Lifecycle."
Jessica Wagoner, Amina Negash, Olivia J. Kane, Laura E. Martinez, Yaakov Nahmias, Nigel Bourne, David M. Owen, Joe Grove, Claire Brimacombe, Jane A. McKeating, Eve-Isabelle Pécheur, Tyler N. Graf, Nicholas H. Oberlies, Volker Lohmann, Feng Cao, John E. Tavis, and Stephen J. Polyak
Hepatology, 2010, 51, 1912-1921.
PMID:20512985; PMCID: PMC2909978; doi: 10.1002/hep.23587
55. "Identification of Hepatoprotective Flavonolignans from Silymarin."
Stephen J. Polyak, Chihiro Morishima, Volker Lohmann, Sampa Pal, David Y. W. Lee, Yanze Liue, Tyler N. Graf, and Nicholas H. Oberlies
Proceedings of the National Academy of Sciences USA, 2010, 107, 5995-5999.
PMID: 20231449; PMCID: PMC2851903; doi: 10.1073/pnas.0914009107
54. "Two Flavonolignans from Milk Thistle (Silybum marianum) Inhibit CYP2C9-Mediated Warfarin Metabolism at Clinically Achievable Concentrations."
Scott J. Brantley, Nicholas H. Oberlies, David J. Kroll, and Mary F. Paine
Journal of Pharmacology and Experimental Therapeutics, 2010, 332, 1081-1087.
PMID:19934397; PMCID: PMC2835426; doi: 10.1124/jpet.109.161927
53. "Large-Scale Isolation of Flavonolignans from Silybum marianum Extract Affords New Minor Constituents and Preliminary Structure-Activity Relationships."
Arlene Sy-Cordero, Tyler N. Graf, Yuka Nakanishi, Mansukh C. Wani, Rajesh Agarwal, David J. Kroll, and Nicholas H. Oberlies
Planta Medica, 2010, 76, 644-647.
PMID:19941262; PMCID: PMC2910627; doi: 10.1055/s-0029-1240624
52. "Isosilybin A Induces Apoptosis in Human Prostate Cancer Cells Via Targeting Akt, NF-kappaB, and Androgen Receptor Signaling."
Gagan Deep, Subhash C. Gangar, Nicholas H. Oberlies, David J. Kroll, and Rajesh Agarwal
Molecular Carcinogenesis, 2010, 49, 902-912.
PMID:20721970; doi: 10.1002/mc.20670
51. "Silymarin Inhibits in Vitro T Cell Proliferation and Cytokine Production in Hepatitis C Virus Infection."
Chihiro Morishima, Margaret C. Shuhart, Chia C. Wang, Denise M. Paschal, Minjun C. Apodaca, Yanze Liu, Derek D. Sloan, Tyler N. Graf, Nicholas H. Oberlies, David Y.–W. Lee, Keith R. Jerome, and Stephen J. Polyak
Gastroenterology, 2010, 138, 671-681.
PMID:19782083; PMCID: PMC2819600; doi: 10.1053/j.gastro.2009.09.021
50. "Influence of Dietary Substances on Intestinal Drug Metabolism and Transport."
Christina S. Won, Nicholas H. Oberlies, and Mary F. Paine
Current Drug Metabolism, 2010, 11, 778-792.
PMID: 21189136; PMCID: PMC3034088; http://www.benthamdirect.org/pages/content.php?CDM/2010/00000011/00000009/0006F.SGM
2009
49. "Mapping of Sample Collection Data: Gis Tools for the Natural Product Researcher."
Nicholas H. Oberlies, James I. Rineer, Feras Q. Alali, Khaled Tawaha, Joseph O. Falkinham III, and William D. Wheaton
Phytochemistry Letters, 2009, 2, 1-9.
PMID: 20161345; PMCID: PMC2774915; doi: 10.1016/j.phytol.2008.10.006
48. "Identification of a Cranberry Juice Product That Inhibits Enteric CYP3A-Mediated First-Pass Metabolism in Humans."
Ngoc Ngo, Zhixia Yan, Tyler N. Graf, Daniel R. Carrizosa, Angela D. M. Kashuba, E. Claire Dees, Nicholas H. Oberlies, and Mary F. Paine
Drug Metabolism and Disposition, 2009, 37, 514-522.
PMID: 19114462; PMCID: PMC2650736; doi: 10.1124/dmd.108.024968
47. "Proliferation of Antibiotic Producing Bacteria and Concomitant Antibiotic Production as the Basis for the Antibiotic Activity of Jordan's Red Soils."
Joseph O. Falkinham III, Thomas E. Wall, Justin R. Tanner, Khaled Tawaha, Feras Q. Alali, Chen Li, and Nicholas H. Oberlies
Applied and Environmental Microbiology, 2009, 75, 2735-2741.
PMID: 19286796; PMCID: PMC2681674; doi: 10.1128/AEM.00104-09
46. "Bioactive Constituents of the Stem Bark of Mitrephora Glabra."
Chen Li, Dongho Lee, Tyler N. Graf, Sharnelle S. Phifer, Yuka Nakanishi, Soedarsono Riswan, Fransisca M. Setyowati, Achmad M. Saribi, Djaja D. Soejarto, Norman R. Farnsworth, III Joseph O. Falkinham III, David J. Kroll, A. Douglas Kinghorn, Mansukh C. Wani, and Nicholas H. Oberlies
Journal of Natural Products, 2009, 72, 1949-1953.
PMID: 19874044; PMCID: PMC2862477; doi: 10.1021/np900572g
45. "Discovery of Anticancer Agents of Diverse Natural Origin."
A. Douglas Kinghorn, Esperanza J. Carcache de Blanco, Hee-Byung Chai, Jimmy Orjala, Norman R. Farnsworth, D. Doel Soejarto, Nicholas H. Oberlies, Mansukh C. Wani, David J. Kroll, Cedric J. Pearce, Steven M. Swanson, Robert A. Kramer, William C. Rose, Craig R. Fairchild, Gregory D. Vite, Stuart Emanuel, David Jarjoura, and Frederick O. Cope
Pure Applied Chemistry, 2009, 81, 1051-1063.
PMID: 20046887; PMCID: PMC2765058; doi: 10.1351/PAC-CON-08-10-16
2008
44. "Microbial-Mediated Release of Bisphenol A from Polycarbonate Vessels."
Nicholas H. Oberlies, Chen Li, Robert J. McGivney, Feras Q. Alali, Justin R. Tanner, and Joseph O. Falkinham III
Letters in Applied Microbiology, 2008, 46, 271-275.
PMID:18069976; doi: 10.1111/j.1472-765X.2007.02301.x
43. "Colchicinoids from Colchicum Crocifolium Boiss.: A Case Study in Dereplication Strategies for (-)-Colchicine and Related Analogs Using LC-MS and LC-PDA Techniques."
Feras Q. Alali, Ahmad Gharaibeh, Abdullah Ghawanmeh, Khaled Tawaha, and Nicholas H. Oberlies
Phytochemical Analysis, 2008, 19, 385-394.
PMID: 18444231; doi: 10.1002/pca.1060
42. "Isosilibinin Inhibits Advanced Human Prostate Cancer Growth in Athymic Nude Mice: Comparison with Silymarin and Silibinin."
Gagan Deep, Komal Raina, Rana P. Singh, Nicholas H. Oberlies, David J. Kroll, and Rajesh Agarwal
International Journal of Cancer, 2008, 123, 2750-2758.
PMID:18798272; doi: 10.1002/ijc.23879
41. "Identifying the Differential Effects of Silymarin Constituents on Cell Growth and Cell Cycle Regulatory Molecules in Human Prostate Cancer Cells."
Gagan Deep, Nicholas H. Oberlies, David J. Kroll, and Rajesh Agarwal
International Journal of Cancer, 2008, 123, 41-50.
PMID:18435416; doi: 10.1002/ijc.23485
40. "Isosilybin B Causes Androgen Receptor Degradation in Human Prostate Carcinoma Cells Via PI3K-Akt-Mdm2-Mediated Pathway."
Gagan Deep, Nicholas H. Oberlies, David J. Kroll, and Rajesh Agarwal
Oncogene, 2008, 27, 3986-3998.
PMID: 18332867; doi: 10.1038/onc.2008.45
39. "Pyrrolizidine Alkaloids from Echium glomeratum (Boraginaceae)."
Feras Q. Alali, Yahya R. Tahboub, Eyad S. Ibrahim, Amjad M. Qandil, Khaled Tawaha, Jason P. Burgess, Arlene Sy, Yuka Nakanishi, David J. Kroll, and Nicholas H. Oberlies
Phytochemistry, 2008, 69, 2341-2346.
PMID:18691727; doi: 10.1016/j.phytochem.2008.06.017
2007
38. "A Novel Small Molecule That Selectively Inhibits Glioblastoma Cells Expressing EGFRvIII."
Dimitri G. Trembath, Anita Lal, David J. Kroll, Nicholas H. Oberlies, and Gregory J. Riggins
Molecular Cancer, 2007, 6, 30.
PMID: 17437646; PMCID: PMC1855066; doi: 10.1186/1476-4598-6-30
37. "Antioxidant Activity and Total Phenolic Content of Aqueous and Methanolic Extracts of Jordanian Plants: An ICBG Project."
Feras Q. Alali, Khaled Tawaha, Tamam El-Elimat, Maha Syouf, Mosa El-Fayad, Khaled Abulaila, Samara Joy Nielsen, William D. Wheaton, Joseph O. Falkinham III, and Nicholas H. Oberlies
Natural Product Research, 2007, 21, 1121-1131.
PMID: 17852749; doi: 10.1080/14786410701590285
36. "Isosilybin B and Isosilybin A Inhibit Growth, Induce G1 Arrest and Cause Apoptosis in Human Prostate Cancer LNCaP and 22Rv1 Cells."
Gagan Deep, Nicholas H. Oberlies, David J. Kroll, and Rajesh Agarwal
Carcinogenesis, 2007, 28, 1533-1542.
PMID: 17389612; doi: 10.1093/carcin/bgm069
35. "Development of a Fluorescence-Based Assay to Screen Antiviral Drugs against Kaposi's Sarcoma Associated Herpesvirus."
Tamara K. Nun, David J. Kroll, Nicholas H. Oberlies, Djaja D. Soejarto, Ryan J. Case, Pius Piskaut, Teatulohi Matainaho, Chelsey Hilscher, Ling Wang, Dirk P. Dittmer, Shou-Jian Gao, and Blossom Damania
Molecular Cancer Therapeutics, 2007, 6, 2360-2370.
PMID: 17699731; doi: 10.1158/1535-7163.MCT-07-0108
34. "Variability in the Yield of Benzophenanthridine Alkaloids in Wildcrafted vs Cultivated Bloodroot (Sanguinaria canadensis L.)."
Tyler N. Graf, Keith E. Levine, Margaret E. Andrews, Jason M. Perlmutter, Samara Joy Nielsen, Jeanine M. Davis, Mansukh C. Wani, and Nicholas H. Oberlies
Journal of Agricultural and Food Chemistry, 2007, 55, 1205-1211.
PMID: 17253712; doi: 10.1021/jf062498f
33. "Alvaradoins E-N, Antitumor and Cytotoxic Anthracenone C-Glycosides from the Leaves of Alvaradoa haitiensis."
Sharnelle S. Phifer, Dongho Lee, Eun-Kyoung Seo, Nam-Cheol Kim, Tyler N. Graf, David J. Kroll, Hernán A. Navarro, Robert A. Izydore, Francisco Jiménez, Ricardo Garcia, William C. Rose, Craig R. Fairchild, Robert Wild, Djaja D. Soejarto, Norman R. Farnsworth, A. Douglas Kinghorn, Nicholas H. Oberlies, Monroe E. Wall, and Mansukh C. Wani
Journal of Natural Products, 2007, 70, 954-961.
PMID: 17552563; PMCID: PMC2442713; doi: 10.1021/np070005a
32. "Gram-Scale Purification of Flavonolignan Diastereoisomers from Silybum marianum (Milk Thistle) Extract in Support of Preclinical in Vivo Studies for Prostate Cancer Chemoprevention."
Tyler N. Graf, Mansukh C. Wani, Rajesh Agarwal, David J. Kroll, and Nicholas H. Oberlies
Planta Medica, 2007, 73, 1495-1501.
PMID: 17948171; doi: 10.1055/s-2007-990239
31. "Milk Thistle Nomenclature: Why It Matters in Cancer Research and Pharmacokinetic Studies."
David J. Kroll, Heather S. Shaw, and Nicholas H. Oberlies
Integrative Cancer Therapies, 2007, 6, 110-119.
PMID: 17548790; doi: 10.1177/1534735407301825
30. "Clinical Relevance of the Small Intestine as an Organ of Drug Elimination: Drug-Fruit Juice Interactions."
Mary F. Paine, and Nicholas H. Oberlies
Expert Opinion on Drug Metabolism & Toxicology, 2007, 3, 67-80.
PMID: 17269895; doi: 10.1517/17425255.3.1.67
2006
29. "A New Colchicinoid from Colchicum tauri, an Unexplored Meadow Saffron Native to Jordan."
Feras Q. Alali, Amani S. Ma'aya'h, Ahmad Alkofahi, Amjad Qandil, Chen Li, Jason P. Burgess, Mansukh C. Wani, and Nicholas H. Oberlies
Natural Product Communications, 2006, 1, 95-99.
28. "Phytochemical Studies and Cytotoxicity Evaluations of Colchicum tunicatum Feinbr and Colchicum hierosolymitanum Feinbr (Colchicaceae): Two Native Jordanian Meadow Saffrons."
Feras Q. Alali, Khaled Tawaha, Tamam El-Elimat, Rana Qasaymeh, Chen Li, Jason Burgess, Yuka Nakanishi, David J. Kroll, Mansukh C. Wani, and Nicholas H. Oberlies
Natural Product Research, 2006, 20, 558-566.
PMID: 16835088; doi: 10.1080/14786410500183381
27. "Dendrimer-Encapsulated Camptothecins: Increased Solubility, Cellular Uptake, and Cellular Retention Affords Enhanced Anticancer Activity in Vitro."
Meredith T. Morgan, Yuka Nakanishi, David J. Kroll, Aaron P. Griset, Michael A. Carnahan, Michel Wathier, Nicholas H. Oberlies,Govindarajan Manikumar, Mansukh C. Wani, and Mark W. Grinstaff
Cancer Research, 2006, 66, 11913-11921.
PMID: 17178889; doi: 10.1158/0008-5472.CAN-06-2066
26. "Simple and Inexpensive Methods to Prevent Botanical Misfortune."
David J. Kroll, Heather S. Shaw, and Nicholas H. Oberlies
Acta Horticulturae, 2006, 720, 137-147.
http://www.actahort.org/books/720/720_13.htm
2005
25. "New Colchicinoids from a Native Jordanian Meadow Saffron, Colchicum brachyphyllum: Isolation of the First Naturally Occurring Dextrorotary Colchicinoid."
Feras Q. Alali, Tamam El-Elimat, Chen Li, Amjad Qandil, Ahmad Alkofahi, Khaled Tawaha, Jason P. Burgess, Yuka Nakanishi, David J. Kroll, Hernán A. Navarro, III Joseph O. Falkinham III, Mansukh C. Wani, and Nicholas H. Oberlies
Journal of Natural Products, 2005, 68, 173-178.
PMID: 15730238; doi: 10.1021/np0496587
24. "Diterpene Glycosides from Egletes viscosa."
Dongho Lee, Chen Li, Tyler N. Graf, Jose Schunke Vigo, James G. Graham, Fernando Cabieses, Norman R. Farnsworth, Geoffrey A. Cordell, A. Douglas Kinghorn, David J. Kroll, Mansukh C. Wani, and Nicholas H. Oberlies
Planta Medica, 2005, 71, 792-794.
PMID: 16142652; doi: 10.1055/s-2005-871227
23. "A Hexacyclic Ent-Trachylobane Diterpenoid Possessing an Oxetane Ring from Mitrephora Glabra."
Chen Li, Dongho Lee, Tyler N. Graf, Sharnelle S. Phifer, Yuka Nakanishi, Jason P. Burgess, Soedarsono Riswan, Fransisca M. Setyowati, Achmad M. Saribi, Djaja D. Soejarto, Norman R. Farnsworth, Joseph O. Falkinham III, David J. Kroll, A. Douglas Kinghorn, Mansukh C. Wani, and Nicholas H. Oberlies
Organic Letters, 2005, 7, 5709-5712.
PMID: 16321028; PMCID: PMC2442714; doi: 10.1021/ol052498l
22. "Milk Thistle and Prostate Cancer: Differential Effects of Pure Flavonolignans from Silybum marianum on Antiproliferative End Points in Human Prostate Carcinoma Cells."
Paula R. Davis-Searles, Yuka Nakanishi, Nam-Cheol Kim, Tyler N. Graf, Nicholas H. Oberlies, Mansukh C. Wani, Monroe E. Wall, Rajesh Agarwal, and David J. Kroll
Cancer Research, 2005, 65, 4448-4457.
PMID: 15899838; doi: 10.1158/0008-5472.CAN-04-4662
21. "The Most Widely Recognized Mushroom: Chemistry of the Genus Amanita."
Chen Li, and Nicholas H. Oberlies
Life Sciences, 2005, 78, 532-538.
PMID: 16203016; doi: 10.1016/j.lfs.2005.09.003
2004
20. "Analysis of Herbal Teas Made from the Leaves of Comfrey (Symphytum officinale): Reduction of N-Oxides Results in Order of Magnitude Increases in the Measurable Concentration of Pyrrolizidine Alkaloids."
Nicholas H Oberlies, Nam-Cheol Kim, Dolores R Brine, Bradley J Collins, Robert W Handy, Charles M Sparacino, Mansukh C Wani, and Monroe E Wall
Public Health Nutrition, 2004, 7, 919-924.
PMID: 15482618; doi: 10.1079/PHN2004624
19. "Cytotoxic and Antimicrobial Constituents of the Bark of Diospyros maritima Collected in Two Geographical Locations in Indonesia."
Jian-Qiao Gu, Tyler N. Graf, Dongho Lee, Hee-Byung Chai, Qiuwen Mi, Leonardus B. S. Kardono, Fransisca M. Setyowati, Rachman Ismail, Soedarsono Riswan, Norman R. Farnsworth, Geoffrey A. Cordell, John M. Pezzuto, Steven M. Swanson, David J. Kroll, Joseph O. Falkinham III, Monroe E. Wall, Mansukh C. Wani, A. Douglas Kinghorn, and Nicholas H. Oberlies
Journal of Natural Products, 2004, 67, 1156-1161.
PMID: 15270571; doi: 10.1021/np040027m
18. "Camptothecin and Taxol: Historic Achievements in Natural Products Research."
Nicholas H. Oberlies, and David J. Kroll
Journal of Natural Products, 2004, 67, 129-135.
PMID: 14987046; doi: 10.1021/np030498t
2003
17. "Synergistic Antimicrobial Activity of Metabolites Produced by a Nonobligate Bacterial Predator."
Cody C. Cain, Dongho Lee, Robert H. Waldo III, Alexis T. Henry, Earl J. Casida Jr., Mansukh C. Wani, Monroe E. Wall, Nicholas H. Oberlies, and Joseph O. Falkinham III
Antimicrobial Agents and Chemotherapy, 2003, 47, 2113-2117.
PMID: 12821455; PMCID: PMC161883; doi: 10.1128/AAC.47.7.2113-2117.2003
16. "Novel Strategies for the Discovery of Plant-Derived Anticancer Agents."
A. Kinghorn, Norman Farnsworth, Djaja Soejarto, Geoffrey Cordell, Steven Swanson, John Pezzuto, Mansukh Wani, Monroe Wall, Nicholas Oberlies, David Kroll, Robert Kramer, William Rose, Gregory Vite, Craig Fairchild, Russell Peterson, and Robert Wild
Pharmaceutical Biology, 2003, 41 (Suppl.), 53-67.
http://informahealthcare.com/doi/abs/10.1080/1388020039051744
2002
15. "Novel Bioactive Clerodane Diterpenoids from the Leaves and Twigs of Casearia sylvestris."
Nicholas H. Oberlies, Jason P. Burgess, Hernán A. Navarro, Rosa Elena Pinos, Craig R. Fairchild, Russell W. Peterson, Djaja D. Soejarto, Norman R. Farnsworth, A. Douglas Kinghorn, Mansukh C. Wani, and Monroe E. Wall
Journal of Natural Products, 2002, 65, 95-99.
PMID: 11858737; doi: 10.1021/np010459m
2001
14. "Bioactive Constituents of the Roots of Licania intrapetiolaris."
Nicholas H. Oberlies, Jason P. Burgess, Hernán A. Navarro, Rosa Elena Pinos, Djaja D. Soejarto, Norman R. Farnsworth, A. Douglas Kinghorn, Mansukh C. Wani, and Monroe E. Wall
Journal of Natural Products, 2001, 64, 497-501.
PMID: 11325234; doi: 10.1021/np0005006
13. "Isolation of Symlandine from the Roots of Common Comfrey (Symphytum officinale) Using Countercurrent Chromatography."
Nam-Cheol Kim, Nicholas H. Oberlies, Dolores R. Brine, Robert W. Handy, Mansukh C. Wani, and Monroe E. Wall
Journal of Natural Products, 2001, 64, 251-253.
PMID: 11430014; doi: 10.1021/np0004653
1998
12. "Cytotoxic and Insecticidal Constituents of the Unripe Fruit of Persea americana."
Nicholas H. Oberlies, Lingling L. Rogers, John M. Martin, and Jerry L. McLaughlin
Journal of Natural Products, 1998, 61, 781-785.
PMID:9644064; doi: 10.1021/np9800304
11. "Myosin Isoform Shifts and Decreased Reactivity in Hypoxia-Induced Hypertensive Pulmonary Arterial Muscle."
C. Subah Packer, Janet E. Roepke, Nicholas H. Oberlies, and Rodney A. Rhoades
American Journal of Physiology, 1998, 274, L775-L785.
PMID: 9612293; http://ajplung.physiology.org/content/274/5/L775.short
1997
10. "The Annonaceous Acetogenin Bullatacin Is Cytotoxic against Multidrug Resistant Human Mammary Adenocarcinoma Cells."
Nicholas H. Oberlies, Vicki L. Croy, Marietta L. Harrison, and Jerry L. McLaughlin
Cancer Letters, 1997, 115, 73-79.
PMID: 9097981; doi: 10.1016/S0304-3835(97)04716-2
09. "Comparative SAR Evaluations of Annonaceous Acetogenins for Pesticidal Activity."
Kan He, Lu Zeng, Qing Ye, Guoen Shi, Nicholas H. Oberlies, Geng-Xian Zhao, C. Jesse Njoku, and Jerry L. McLaughlin
Pesticide Science, 1997, 49, 372-379.
doi: 10.1002/(SICI)1096-9063(199704)49:4<372::AID-PS543>3.0.CO;2-K
08. "Oleanolic Acid, a Bioactive Component of the Leaves of Ocimum gratissimum (Lamiaceae)."
C.J. Njoku, Lu Zeng, I.U. Asuzu, Nicholas H. Oberlies, and Jerry L. McLaughlin
Pharmaceutical Biology, 1997, 35, 134-137.
doi: 10.1076/phbi.35.2.134.13290
07. "Structure-Activity Relationships of Diverse Annonaceous Acetogenins against Multidrug Resistant Human Mammary Adenocarcinoma (MCF-7/Adr) Cells."
Nicholas H. Oberlies, Ching-jer Chang, and Jerry L. McLaughlin
Journal of Medicinal Chemistry, 1997, 40, 2102-2106.
PMID: 9207950; doi: 10.1021/jm9700169
1996
06. "Longimicins A-D: Novel Bioactive Acetogenins from Asimina longifolia (Annonaceae), and Structure Activity Relationships of Asimicin Type Annonaceous Acetogenins."
Qing Ye, Kan He, Nicholas H. Oberlies, Lu Zeng, Guoen Shi, Dean Evert, and Jerry L. McLaughlin
Journal of Medicinal Chemistry, 1996, 39, 1790-1796.
PMID: 8627602; doi: 10.1021/jm9600510
05. "Five New Monotetrahydrofuran Ring Acetogenins from the Leaves of Annona muricata."
Lu Zeng, Feng-E Wu, Nicholas H. Oberlies, and Jerry L. McLaughlin
Journal of Natural Products, 1996, 59, 1035-1042.
PMID: 8946744; doi: 10.1021/np960447e
04. "Recent Advances in Annonaceous Acetogenins." Lu Zeng, Qing Ye, Nicholas H. Oberlies, Guoen Shi, Zhe-Ming Gu, Kan He, and Jerry L. McLaughlin
Natural Products Reports, 1996, 13, 275-306.
PMID: 8760865; doi: 10.1039/NP9961300275
1995
03. "Tumor Cell Growth Inhibition by Several Annonaceous Acetogenins in an in Vitro Disk Diffusion Assay."
Nicholas H. Oberlies, Julie L. Jones, Thomas H. Corbett, Sophia S. Fotopoulos, and Jerry L. McLaughlin
Cancer Letters, 1995, 96, 55-62.
PMID: 7553608; doi: 10.1016/0304-3835(95)92759-7
02. "Mode of Action of Bullatacin, a Potent Antitumor Acetogenin: Inhibition of NADH Oxidase Activity of HeLa and HL-60, but Not Liver, Plasma Membranes."
D. James Morré, Rafael de Cabo, Christopher Farley, Nicholas H. Oberlies, and Jerry L. McLaughlin
Life Sciences, 1995, 56, 343-348.
PMID: 7837933; doi: 10.1016/0024-3205(94)00957-0
1993
01. "The Electrochemical Preparation and Kinetic and Product Studies of Acylated Quinol and Quinol Ether Imines - in Search of the Hydrolysis Products of the Ultimate Carcinogen of N-Acetyl-2-Aminofluorene."
Michael Novak, John S. Helmick, Nicholas Oberlies, Kanchugarakoppal S. Rangappa, William M. Clark, and John S. Swenton
Journal of Organic Chemistry, 1993, 58, 867-878.
doi: 10.1021/jo00056a019
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