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Cech Research Group



41. "Echinacea purpurea extracts contain a mixture of cytokine-suppressive and cytokine-inducing compounds, including some that originate from endophytic bacteria." 
Daniel A. Todd, Tyler V. Gulledge, Emily R. Britton, Martina Oberhofer, Martha Leyte-Lugo, Ashley A. Moody, Tatsiana Shymanovich, Laura F. Grubbs, Monika Juzumaite, Tyler N. Graf, Nicholas H. Oberlies, Stanley H. Faeth, Scott M. Laster, Nadja B. Cech .
Plos One, In press.

40. "A mass spectrometry-based assay for improved quantitative measurements of efflux inhibition." 
Adam R. Brown, Keivan A. Ettefagh, Daniel A. Todd, Patrick S. Cole, Joseph M. Egan, Daniel H. Foil, Tyler N. Graf, Bryan D. Schindler, Glen W. Kaatz, Nadja B. Cech.
Plos One, In press.


39. "Comparison of the chemistry and diversity of endophytes isolated from wild-harvested and greenhouse-cultivated yerba mansa (Anemopsis californica)." 
R. Owen Bussey III, Amninder Kaur, Daniel A. Todd, Joseph M. Egan, Tamam El-Elimat, Tyler N. Graf, Huzefa A. Raja, Nicholas H. Oberlies, Nadja B. Cech.
Phytochemistry Letters, 11, 202-208.
PMID: 25642298; doi:10.1016/j.phytol.2014.12.013

38. "Investigations of analyte-specific response saturation and dymanic range limitations in atmospheric pressure ionization mass spectrometry." 
Clint Alfaro, Agbo-Oma Uwakweh, Daniel A. Todd, Brandie M. Ehrmann, Nadja B. Cech.
Analytical Chemistry, 86, (21), 10639-10645.
PMID:25268329; doi: 10.1021/ac502984a

37. "Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry." 
Mario Figueroa, Alan K. Jarmusch, Huzefa A. Raja, Tamam El-Elimat, Jeffrey S. Kavanaugh, Alexander R. Horswill, R. Graham Cooks, Nadja B. Cech, Nicholas H. Oberlies.
Journal of Natural Products, 77, 1351-1358.
PMID:24911880; doi: 10.1021/np5000704

36. "Staphylococcus epidermidis agr quorum-sensing system: Signal identification, cross talk, and importance in colonization." 
Michael E. Olson, Daniel A. Todd, Carolyn R. Schaeffer, Alexandra E. Paharik, Michael J. Van Dyke, Henning Buttner, Paul M. Dunham, Holger Rohde, Nadja B. Cech, Paul D. Fey, Nadja B. Cech, Alexander R. Horswill.
Journal of Bacteriology, 196, 3482-3493.
PMID:25070736; doi: 10.1128/JB.01882-14

35. "Identification of morphological and chemical markers of dry- and wet-season conditions in female Anopheles gambiae mosquitoes." 
Kaira M. Wagoner, Tovi Lehmann, Diana L. Huestis, Brandie M. Ehrmann, Nadja B. Cech, Gideon Wasserberg.
Parasites & Vectors, 7, 294.
PMID:24970701; doi: 10.1186/1756-3305-7-294

34. "Antimycobacterial furofuran lignans from the roots of Anemopsis californica." 
R. Owen Bussey III, Arlene A. Sy-Cordero, Mario Figueroa, Fred S. Carter, Joseph O. Falkinham III, Nicholas H. Oberlies, Nadja B. Cech.
Planta Medica, 80, 498-501.
PMID:24687738; doi: 10.1055/s-0034-1368352

33. "CodY-mediated regulation of the Staphylococcus aureus Agr system integrates nutritional and population density signals." 
Agnès Roux, Daniel A. Todd, Jose V. Velázquez, Nadja B. Cech, and Abraham L. Sonenshein.
Journal of Bacteriology, Epub ahead of print.
PMID:24391052; doi: 10.1128/JB.00128-13

32. "Flavonolignans from Aspergillus iizukae, a fungal endophyte of milk thistle (Silybum marianum)." 
Tamam El-Elimat, Huzefa A. Raja, Tyler N. Graf, Stan H. Faeth, Nadja B. Cech, and Nicholas H. Oberlies.
Journal of Natural Products, Epub ahead of print.
PMID:24456525; doi: 10.1021/np400955q


31. "Small molecule quorum quenchers for prevention of Staphylococcus aureus infection." 
Nadja B. Cech and Alexander R. Horswill. 
Future Microbiology, (Editorial), 8, 1-4
PMID:24266350; doi: 10.2217/fmb.13.134

30. "Strategies and pitfalls in the application of mass spectrometry to natural products research." 
Nadja B. Cech.
LC-GC, 31

29. "A high-resolution MS, MS/MS, and UV database of fungal secondary metabolites as a dereplication protocol for bioactive natural products." 
Tamam El-Elimat, Mario Figueroa, Brandie M. Ehrmann, Nadja B. Cech, Cedric Pearce, and Nicholas H. Oberlies.
Journal of Natural Products, 76, 1709-1716
PMID:23947912; doi: 10.1021/np4004307

28. "Rapid quantitation of furanocoumarins and flavonoids in grapefruit juice using ultra performance liquid chromatography." 
Karen M. Vandermolen, Nadja B. Cech, Mary F. Paine, and Nicholas H. Oberlies.
Phytochemistry, 24, 654-660
PMID:23780830; doi: 10.1002/pca.2449

27. "Quantitative analysis of autoinducing peptide I (AIP-I) from Staphylococcus aureus cultures using ultrahigh performance liquid chromatography – high resolving power mass spectrometry." 
Hiyas A. Junio, Daniel A. Todd, Keivan A. Ettefagh, Brandie M. Ehrmann, Jeffrey S. Kavanaugh, Alexander H. Horswill, and Nadja B. Cech.
Journal of Chromatography B, 930, 7-12
PMID:23703543; doi: 10.1016/j.jchromb.2013

26. "Sarothrin from Alkanna orientalis is an antimicrobial agent and efflux pump inhibitor." 
Jessica R. Bame, Tyler N. Graf, Hiyas A. Junio, R. Owen Bussey, Scott A. Jarmusch, Tamam El-Elimat, Joseph O. Falkinham, Nicholas H. Oberlies, Richard A. Cech, and Nadja B. Cech.
Planta Medica, 79, 327-329
PMID:23468310; doi: 10.1055/s-0032-1328259


25. "Quorum Quenching and Antimicrobial Activity of Goldenseal (Hydrastis canadensis ) against Methicillin-Resistant Staphylococcus aureus (MRSA)." 
Nadja B. Cech, Hiyas A. Junio, Laynez W. Ackermann, Jeffrey S. Kavanaugh, and Alexander H. Horswill. 
Planta Medica, 2012, 78, 1556-1561

24. "Maplexins, new α-glucosidase inhibitors from red maple (Acer rubrum) stems." 
Chunpeng Wan, Tao Yuan, Vamsikrishna Kandhi, Nadja B. Cech, Mingyong Xie, and Navindra P. Seeram. 
Bioorganic and Medicinal Chemistry Letters, 22, 567-600
PMID:22079755; doi: 10.1002/chin.201221211


23. "Phenolic glycosides from sugar maple (Acer saccharum) bark." 
Tao Yuan, Chunpeng Wan, Antonio Gonzalez-Sarrias, Vamsikrishna Kandhi, Nadja B. Cech, and Navindra P. Seeram. 
Journal of Natural Products, 742472-2476
PMID:22032697; doi: 10.1021/np200543z

22. "Synergy Directed Fractionation of Botanical Medicines: A Case Study with Goldenseal (Hydrastis canadensis)." 
Hiyas A. Junio, Arlene A. Sy-Cordero, Keivan A. Ettefagh, Johnna T. Burns, Kathryn T. Micko, Tyler N. Graf, Scott J. Richter, Robert E. Cannon, Nicholas H. Oberlies, and Nadja B. Cech. 
Journal of Natural Products, 74, 1621-1629
PMCID:PMC3142294; doi: 10.1021/np200336g

21. "Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by the isoquinoline alkaloid berberine and extracts of goldenseal (Hydrastis canadensis)." 
Chad E. Cecil, Jeanine M. Davis, Nadja B. Cech, and Scott M. Laster. 
Intertational Immunopharmacology, 11, 1706-1714
PMID:21683808; doi: 10.1016/j.intimp.2011.06.002


20. "Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition." 
Keivan A. Ettefagh, Johnna T. Burns, Hiyas A. Junio, Glenn W. Kaatz, and Nadja B. Cech. 
Planta Medica, 77, 835-840
PMCID: PMC3100400; doi: 10.1055/s-0030-1250606

19. "Echinacea and its alkylamides: effects on the influenza A-induced secretion of cytokines, chemokines, and PGE from RAW 264.7 macrophage-like cells."
Nadja B. Cech, Vamsikrishna Kandhi, Jeanine M. Davis, Amy Hamilton, Dawn Eads, and Scott M. Laster. 
Intertational Immunopharmacology, 10, 1268-1278
PMID: 21683808; doi: 10.1016/j.intimp.2010.07.009

18. "Selectivity in Electrospray Ionization Mass Spectrometry."
Nadja B. Cech, and Christie G. Enke. 
In: Electrospray and MALDI Mass Spectrometry, Ed. Cole, R.B. 2nd Edition, 49-73

17. "A Validated Liquid Chromatography/Electrospray Ionization-Mass Spectrometry (LC/ESI-MS) Method for Quantification of Spilanthol in Spilanthes acmella (L.) Murr."
Stacy S. Bae, Brandie M. Ehrmann, Keivan A. Ettefagh, and Nadja B. Cech. 
Phytochemical Analysis, 21, 438-443
PMID: 20310072; doi: 10.1002/pca.1215


16. "Comparison of alkylamide yield in ethanolic extracts prepared from fresh versus dry Echinacea purpureautilizing HPLC-ESI-MS"
Kevin Spelman, Matthew Wetschler, and Nadja B. Cech. 
Journal of Pharmaceutical and Biomedical Analysis, 49, 1141-1149
PMCID: PMC2745817; doi: 10.1016/j.jpba.2009.02.011

15. "Role for PPAR <gamma> in IL-2 inhibition in T cells by Echinacea-derived undeca-2E-ene-8,10- diynoic acid isobutylamide."
Kevin Spelman, Katrina Liams-Hauser, Nadja B. Cech, Ethan Will Taylor, Nicholas Smirnoff, and Cynthia A. Wenner. 
International Immunopharmacology, 91260-1264
PMID:19712756; doi: 10.1016/j.intimp.2009.08.009


14. "Relative Importance of Basicity in the Gas Phase and in Solution for Determining Responsiveness to Electrospray Ionization Mass Spectrometry."
Brandie M. Ehrmann, Trina Henriksen, and Nadja B. Cech. 
Journal of the American Society for Mass Spectrometry, 19719-728
PMID: 18325781; doi: 10.1016/j.jasms.2008.01.003


13. "Changes in floral color and anthocyanin production in Plantago lanceolata in response to temperature."
Elizabeth A. Stiles, Nadja B. Cech, Stacy M. W. Dee, and Elizabeth P. Lacey. 
Physiologia Plantarum, 129, 756-765

12. "Effects of Herbal Products and their constituents on Human Cytochrome P4502E1 Activity."
Gregory M. Raner, Sean Cornelius, Kamalika Moulick, Yingqing Wang, Ashley M. Mortenson, Jonathan Hill, Connell Cunningham, and Nadja B. Cech. 
Food and Chemical Toxicology, 45, 2359-2365
PMCID: PMC2955861; doi: 10.1016/j.fct.2007.06.012


11. "Echinacea alkylamides inhibit interleukin-2 production by Jurkat human T cells."
Masa Sasagawa, Nadja B. Cech, Dean E. Gray, Gary W. Elmer, and Cynthia A. Wenner. 
International Immunopharmacology, 61214-1221
PMID:16714226; doi: 10.1016/j.intimp.2006.02.003

10. "Liver enzyme-mediated oxidation of Echinacea purpurea alkylamides: Production of novel metabolites and changes in immunomodulatory activity. "
Nadja B. Cech, Katrina Tutor, Bethany A. Doty, Kevin Spelman, Masa Sasagawa, Gregory M. Raner, and Cynthia A. Wenner.
Planta Medica, 751372-1377
PMID: 17054047; doi: 10.1055/s-2006-951718

9. "Electrospray ionization mass spectrometry: How and when it works."
Nadja B. Cech, and Christie G. Enke. 
Encyclopedia of Mass Spectrometry, 8171-180

8. "High performance liquid chromatography/electrospray ionization mass spectrometry for simultaneous analysis of alkylamides and caffeic acid derivatives from Echinacea purpurea extracts."
Nadja B. Cech, Maqueita S. Eleazer, Lawresa T. Shoffner, Amanda C. Davis, Mark R. Crosswhite, and Ashley M. Mortenson.
Journal of Chromatography A, 1103219-228
PMID: 16298376; doi: 10.1016/j.chroma.2005.11.008


7. "The relative influences of acidity and polarity on responsiveness of small organic molecules to analysis with negative ion electrospray ionization mass spectrometry (ESI-MS)."
Trina Henriksen, Renee K. Juhler, Bo Svensmark, and Nadja B. Cech. 
Journal of the American Society for Mass Spectrometry, 16, 446-455
PMID: 15792713; doi: 10.1016/j.jasms.2004.11.021


6. "Practical implications of some recent studies in electrospray ionization fundamentals."
Nadja B. Cech, and Christie G. Enke. 
Mass Spectrometry Reviews, 20362-287
PMID: 11997944; doi: 10.1002/mas.10008


5. "Electrospray ionization detection of an inherently nonresponsive epoxide by peptide binding."
Nadja B. Cech, Jennifer R. Krone, and Christie G. Enke. 
Rapid Communications in Mass Spectrometry, 151040-1044
PMID:11404839; doi: 10.1002/rcm.337

4. "Predicting electrospray response from chromatographic retention time."
Nadja B. Cech, Jennifer R. Krone, and Christie G. Enke. 
Analytical Chemistry, 73, 208-213
PMID: 11199967; doi: 10.1021/ac0006019

3. "The effect of affinity for charged droplet surfaces on the fraction of analyte charged in the electrospray process."
Nadja B. Cech, and Christie G. Enke. 
Analytical Chemistry, 73, 4632-4639
PMID:11605841; doi: 10.1021/ac001267j


2. "Relating electrospray ionization response to non-polar character of small peptides."
Nadja B. Cech, and Christie G. Enke. 
Analytical Chemistry, 72, 2717-2723
PMID:10905298; doi: 10.1021/ac9914869


1. "Electrospray ionization mass spectrometric analysis of blood for differentiation of species."
Edgard O. Espinoza, Nadja B. Cech, Kathy M. Gordon, Jessica Ekhoff, and Mark A. Kirms. 
Analytical Biochemistry, 268, 252-261
PMID:10075815; doi: 10.1006/abio.1998.3048