Publications

 

  1. Fortin, S.; Wei, L.; Moreau, E.; Labrie, P.; Peritclerc, E.; Kotra, L. P.; Gaudreault, R. C.  Mechanism of actionof N-phenyl-N’-(2-chloroethyl)ureas in the colchicines-binding site at the interface between - and -tubulin.  Bioorg. Med. Chem.  2009, in press.
  2. Fujihashi, M.; Wei, L.; Kotra, L. P.; Pai, E. F.  Structural characterization of the molecular events during a slow substrate-product transition in Orotinde-5’-monophosphate decarboxylase.  J. Mol. Biol.  2009, 387, 1199-1210. (Direct link to the article)
  3. Bello, A. M.; Konforte, D.; Poduch, E.; Furlonger, C.; Wei, L.; Liu, Y.; Lewis, M.; Pai, E. F.; Paige, C. J.; Kotra, L. P.  Structure-activity relationships of orotidine-5’-monophosphate decarboxylase inhibitors as anticancer agents.  J. Med. Chem.  2009, 52, 1648–1658. (Direct link to the article)
  4. Bello, A. M.; Bende, T.; Wei, L.; Fish, E. N.; Kotra, L. P.  De novo design of nonpeptidic compounds targeting the interactions between interferon-a and its cognate cell surface receptor.  J. Med. Chem.  2008, 51, 2734-2743. (Direct link to the article)
  5. Tang, S.; Xiao, V.; Wei, L.; Whiteside, C. I.; Kotra, L. P.  Protein kinase C isozymes and their selectivity towards ruboxistaurin.  Proteins Struct. Function & Bioinform.  2008, 72, 447-460. (Direct link to the article)
  6. Fortin, S.; Labrie, P.; Moreau, E.; Wei, L.; Kotra, L. P.; C.-Gaudreault, R.  A Comparative Molecular Field and Comparative Molecular Similarity Indices Analyses (CoMFA and CoMSIA) of N-Phenyl-N’-(2-chloroethyl)urea Targeting the Colchicine-Binding Site as Anticancer Agents.  Bioorg. Med. Chem.  2008, 16, 1914-1926. (Direct link to the article) 
  7. Bello, A. M.; Poduch, E.; Liu, Y.; Wei, L.; Crandall, I.; Wang, X.; Dyanand, C.; Kain, K. C.; Pai, E. F.; Kotra, L. P.  Structure-Activity Relationships of C6-Uridine Derivatives Targeting Plasmodia Orotidine Monophosphate decarboxylase.  J. Med. Chem. 2008, 51 (3), 439–448. (Direct link to the article)
  8. Poduch, E.; Wei, L.; Pai, E. F.; Kotra, L. P.  Structural Diversity and Plasticity Associated with Nucleotides targeting Orotidine Monophosphate Decarboxylase.  J. Med. Chem. 2008, 51 (3), 432–438. (Direct link to the article)
  9. Meza-Avina, M. E.; Wei, L.; Buhendwa, M. G.; Poduch, E.; Bello, A. M.; Pai, E. F.; Kotra, L. P. Inhibition of Orotidine 5’-Monophosphate Decarboxylase and Its Therapeutic Potential.  Mini-Rev. Med. Chem. 2008, 8(3), 239-247.
  10. Kumaran, J.; Wei, L.; Kotra, L. P., Fish, E. N.  A structural basis for interferon--receptor interactions.  FASEB J.  2007, 21, 3288-3296. (Direct link to the article)
  11. Bello, A. M.; Poduch, E.; Fujihashi, M.; Amani, M.; Li, Y.; Crandall, I.; Hui, R.; Lee, P. I.; Kain, K. C.; Pai, E. F.; Kotra, L. P.  A potent, covalent inhibitor of orotidine 5’-monophosphate decarboxylase with antimalarial activity.  J. Med. Chem.  2007, 50(5), 915-921. (Direct link to the article)

>>Read the PRESS RELEASE on this research work.

  1. Wang, X.; Wei, L.; Kotra, L. P.  Cyanocobalamin (vitamin B12) conjugates with enhanced solubility.  Bioorg. Med. Chem.  2007, 15, 1780-1787. (Direct link to the article)
  2. Labrie, P.; Maddaford, S. P.; Fortin, S.; Rakhit, S.; Kotra, L. P.; C.-Gaudreault, R.  A Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) of Anthranilamide Derivatives that are Multidrug Resistance Modulators.  J. Med. Chem. 2006, 49(26), 7646-7660. (Direct link to the article)
  3. Poduch, E.; Bello, A. M.; Tang, S.; Fujihashi, M.; Pai, E. F.; Kotra, L. P.  Design of inhibitors of orotidine monophosphate decarboxylase using bioisisteric replacement and determination of inhibitor kinetics.  J. Med. Chem. 2006, 49, 4937-4945. (Direct link to the article)
  4. Annedi, S. C.; Biabani, F.; Poduch, E.; Mannargudi, B. M.; Majumder, K.; Wei, L.; Khayat, R.; Tong, L.; Kotra, L. P.  Engineering D-amino acid containing Novel Protease Inhibitors using Catalytic Site Architecture.  Bioorg. Med. Chem.  2006, 14, 214-236.
  5. Oyiliagu, C.; Novalen, M.; Kotra, L. P.  Fluorine containing molecules for peptidomimicry: A chemical act to modulate enzymatic activity.  Mini-Rev. Org. Chem.  2006, 3, 99-115.
  6. Gallant, C. V.; Daniels, C.; Leung, J. M.; Ghosh, A. S.; Young, K. D.; Kotra, L. P.; Burrows, L. L.  Common b-lactamases inhibit bacterial biofilm formation.  Mol. Microbiol.  2005, 58, 1012-1024  (Direct link to the article)
  7. Fujihashi, M.; Bello, A. M.; Poduch, E.; Wei, L.; Annedi, S. C.; Pai, E. F.; Kotra, L. P.  An unprecedented twist for ODCase catalytic activity.  J. Am. Chem. Soc. 2005, 127, 15048-15050 (Direct link to the article).
  8. Annedi, S. C.; Biabani, F.; Poduch, E.; Mannargudi, B. M.; Majumder, K.; Wei, L.; Khayat, R.; Tong, L.; Kotra, L. P.  Engineering D-amino acid containing Novel Protease Inhibitors using Catalytic Site Architecture.  Bioorg. Med. Chem.  2005, 14, 214-236 (Direct link to the article).
  9. Annedi, S. C.; Majumder, K.; Wei, L.; Oyiliagu, C. E.; Samson, S.; Kotra, L. P.  Novel fluoropeptidomimetics:  Synthesis, stability studies and protease inhibition.  Bioorg. Med. Chem.  2005, 13, 2943-2958. (Direct Link to the article)
  10. Tan, C.; Wei, L.; Ottensmeyer, F. P.; Goldfine, I.; Maddux, B. A.; Yip, C. C.; Batey, R. A.; Kotra, L. P.  Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor.  Bioorg. Med. Chem. Lett. 2004, 14, 1407-1410. [Special Section on “Therapeutic Intervention Targeting Protein-Protein Interactions” Edited by J. Chmielewski] (Direct Link to the article).

>>Read the PRESS RELEASE on this research work.

  1. Bello, A. M.; Kotra, L. P.  Improved synthesis of pyrylium salts leading to 2,4-disubstituted diarylfurans via novel mechanism.  Tet. Lett. 2003, 44 (52), 9271-9274. (Direct Link to the article)
  2. Kuang, D.; Yao, Y.; Wang, M.; Pattabhiraman, N.; Kotra, L. P.; Hampson, D. R.  Molecular similarities in the ligand binding pockets of an odorant receptor and the metabotropic glutamate receptors.  J. Biol. Chem.  2003, 278 (43), 42551-42559. (Direct Link to the article)
  3. Annedi, S. C.; Li, W.; Samson, S.; Kotra L. P.  Design and synthesis of novel fluoropeptidomimetics as potential mimics of the transition state during peptide hydrolysis.  J. Org. Chem. 2003, 68, 1043-1049. (Direct Link to the article)
  4. Kuang, D.; Yao, Y.; Wang, M.; Pattabhiraman, N.; Kotra, L. P.; Hampson, D. R.  Molecular similarities in the ligand binding pockets of an odorant receptor and the metabotropic glutamate receptors.  J. Biol. Chem.  2003, 278 (43), 42551-42559.
  5. Kotra, L. P.; Zhang, L.; Fridman, R.; Orlando, R.; Mobashery, S. N-Glycosylation Pattern of the Zymogenic Form of Human Matrix Metalloproteinase-9.  Bioorg. Chem. 2002, 30, 356-370.
  6. Toth, M.; Hernandez-Barrantes, S.; Osenkowski, P.; Bernardo, M. M.; Gervasi, D. C.; Shimura, Y.; Meroueh, O.; Kotra, L. P.; Arroyo, A. G.; Mobashery, S.; Fridman, R.  Complex pattern of membrane type 1-matrix metaloproteinase shedding.  Regulation by autocatalytic cell surface inactivation of active enzyme.  J. Biol. Chem. 2002, 277, 26340-26350.
  7. Llano-Sotelo, B.; Azucena, E. F., Jr.; Kotra, L. P.; Mobashery, S.; Chow, C. S.  Aminoglycosides Modified by Resistance Enzymes Display Diminished Binding to the Bacterial Ribosomal Aminoacyl-tRNA Site.  Chem. Biol.  2002, 9 (4), 455-463.
  8. Nampalli, S.; Zhang, W.; Rao, T. S.; Xiao, H.; Kotra, L. P.; Kumar, S.  Unnatural Amino Acid Derived FRET Cassettes, Terminators and Their DNA Sequencing Potential.  Tetrahedron Lett.  2002, 43, 1999–2003.
  9. Haddad, J.; Kotra, L. P.; Llano-Sotelo, B.; Kim, C.; Azucena Jr., E. F.; Liu, M.; Vakulenko, S. B.; Chow, C. S.; Mobashery, S.  Design of Novel Antibiotics that Bind to the Ribosomal Acyltransfer Site.  J. Am. Chem. Soc.  2002, 124(13), 3229-3237.
  10. Kridel, S. J.; Chen, E.; Kotra, L. P.; Howard, E. W.; Mobashery, S.; Smith, J. M.  Substrate hydrolysis by matrix metalloproteinase-9.  J. Biol. Chem.  2001, 276 (23), 20572-20578.
  11. Kleifeld, O.; Kotra, L. P.; Gervasi, D. C.; Brown, S.; Bernardo, M. M.; Fridman, R.; Mobashery, S.; Sagi, I.  X-Ray absorption studies of a highly selective mechanism-based inhibitor bound to the human matrix metalloproteinase-2 (MMP-2): Comparison to the latent and active forms of the enzyme.  J. Biol. Chem.  2001, 276 (20), 17125-17131.
  12. Kotra, L. P.; Cross, J.B.; Fridman, R.; Schlegel, H. B.; Mobashery, S.  Insight into the complex process of activation of matrix metalloproteinases.  J. Am. Chem. Soc.  2001, 123, 3108-3113.
  13. Lee, W.; McDonough, M. A.; Kotra, L. P.; Lee, Z.-H.; Silvaggi, N. R.; Takeda, Y.; Kelly, J. A.; Mobashery, S.  A 1.2-Å snapshot of the final step of bacterial cell wall biosynthesis.  Proc. Natl. Acad. Sci. USA  2001, 98, 1427-1431.
  14. Liu, M.; Haddad, J.; Azucena, E.; Kotra, L. P.; Kirzhner, M.; Mobashery, S.  Tethered bi-substrate derivatives as probes for mechanism and as inhibitors of aminoglycoside 3’-phosphotransferases.  J. Org. Chem.  2000, 65(22), 7422-7431.
  15. Ishiwata, A.; Kotra, L. P.; Miyashita, K.; Nagase, T.; Mobashery, S.  Stereoselective reduction of -bromopenicillanates by tributylphosphine. Org. Lett.  2000, 2, 2889-2892.
  16. Brown, S.; Bernando, M. M.; Li, Z.-H.; Kotra, L. P.; Tanaka, Y.; Fridman, R.; Mobashery, S.  Selective mechanism-based inhibition of matrix metalloproteases.  J. Am. Chem. Soc.  2000, 122, 6799-6800.
  17. Golemi, D.; Maveuraud, L.; Vakulenko, S.; Tranier, S.; Ishiwata, A.; Kotra, L. P.; Samama, J.-P.; Mobashery, S.  The first structural and mechanistic insights for class D -lactamases: Evidence for a novel catalytic process for turnover of -lactam antibiotics.  J. Am. Chem. Soc.  2000, 122, 6132-6133.
  18. Kotra, L. P.; Vakulenko, S.; Mobashery, S.  From genes to sequences to antibiotics:  Prospects for future developments from microbial genomics.  Microbes Infect.  2000, 2, 651-658 (Review article)
  19. Therrien, C.; Kotra, L. P.; Sanchagrin, F.; Mobashery, S.; Levesque, R. C.  Evaluation of inhibition of the carbenicillin-hydrolyzing -lactamase PSE-4 by the clinically used mechanism-based inhibitors.  FEBS Lett.  2000, 470, 285-292.
  20. Amro, N. A.; Kotra, L. P.; Wadu-Mesthrige, K.; Bulychev, A.; Mobashery, S.; Liu, G. Y. High resolution atomic force microscopy studies of the Escherichia coli outer membrane:  Structural basis for permeability.  Langmuir  2000, 16, 2789-2796.
  21. Olson, M. W.; Bernardo, M. M.; Pietila, M.; Gervasi, D. C.; Toth, M.; Kotra, L. P.; Massova, I.; Mobashery, S.; Fridman, R.  Characterization of the monomeric and dimeric forms of latent and active matrix metalloproteinase-9.  Differential rates for activation by stromelysin 1.   J. Biol. Chem.  2000, 275, 2661-2668.
  22. Amro, N. A.; Kotra, L. P.;   Wadu-Mesthrige, K.; Bulchev, A.; Mobashery, S.; Liu, G-Y.  Structural basis of the Escherichia coli outer-membrane permeability.  Proc. SPIE  1999, 3607, 108-122.
  23. Kotra, L. P.; Mobashery, S.  Mechanistic and clinical aspects of -lactams and -lactamases. Arch. Immunol. Ther. Ex.  1999, 47(4), 211-216 (Review Article).
  24. Kotra, L.P.;  Golemi, D.; Amro, N.; Liu, G.Y.; Mobashery, S.  Dynamics of the lipopolysaccharide assembly on the surface of Escherichia coli.  J. Am. Chem. Soc.  1999, 121, 8707-8711.
  25. Mourey, L.; Kotra, L. P.; Bellettini, J.; Bulychev, A.; O'Brien, M.; Miller, M. J.; Mobashery, S.; Samama, J. P.  Inhibition of the broad-spectrum NMC-A -lactamase from Enterobacter cloacae by monocyclic -lactams.  J. Biol. Chem.  1999,274, 25260-25265.
  26. Swarén, P.;  Massova, I.;  O'Brien, M.; Bulychev, A.; Maveyraud, L.; Kotra, L. P.; Miller, M. J.;  Mobashery, S.;  Samama, J. P.  Elucidation of mechanism of inhibition and X-ray structure of the TEM-1 -lactamase from Escherichia coli inhibited by a N-sulfonyloxy--lactam.  J. Am. Chem. Soc.  1999, 121, 5353-5359.
  27. Wang, P.P.; Kotra, L. P.; Chu, C. K.; Bartlett, M. G.  Structural characterization of 4-azido-2-pyrimidinone nucleosides using mass spectrometry.  J. Mass Spectr.  1999, 34, 724-732.
  28. Li, Z.-H.; Bulychev, A.; Kotra, L. P.; Massova, I.; Mobashery, S.  Hydrogen bonding and attenuation of the rate of enzymic catalysis.  J. Am. Chem. Soc.  1998, 120, 13003-13007.
  29. Maveyraud, L.; Mourey, L.; Kotra, L. P.; Pedelacq, J.-D.; Guillet, V.; Mobashery, S.; Samama, J. P.  Structural basis for clinical longevity of carbapenem antibiotics in the face of challenge by the common class A -lactamases from the antibiotic-resistant bacteria.  J. Am. Chem. Soc.  1998, 120, 9748-9752.
  30. Vakulenko, S. B.; Geryk, B.; Kotra, L. P.; Mobashery, S.; Lerner, S. A.  Selection and characterization of b-lactam/b-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 b-lactamase gene.  Antimicrob. Agents Chemother.  1998, 43, 1542-1548.
  31. Kotra, L. P.; Newton, M. G.; Chu, C. K.  Synthesis of 2,3-dideoxy-2,2-difluoro-L-glycero-pentofuranosyl nucleosides.  Carbohydr. Res.  1998, 306, 69-80.
  32. Massova, I.; Kotra, L. P.; Mobashery, S.  Structural insight into the binding motifs for the calcium ion and the non-catalytic zinc in matrix metalloproteases.  Bioorg. Med. Chem. Lett.  1998, 8, 853-858.
  33. Kotra, L. P.; Xiang, Y. -J.; Newton, M. G.; Schinazi, R. F.; Cheng, Y. -C.; Chu, C. K.  Structure-activity relationships of 2'-deoxy-2',2'-difluoro-L-erythro-pentofuranosyl nucleosides.  J. Med. Chem.  1997, 40, 3635-3644.
  34. Kotra, L. P.; Wang, P. P.; Bartlett, M. G.; Shanmuganathan, K.; Xu, Z. -S.; Cavalcanti, S.; Newton, M. G.; Chu, C. K.  4-Azido-2-pyrimidinone nucleosides and related chemistry.  J. Org. Chem.  1997, 62, 7267-7271.
  35. Kotra, L. P.; Manouilov, K. K.; Sommadossi, J. -P.; Boudinot, F. D.; Schinazi, R. F.; Chu, C. K.  Synthesis, biotransformation, and pharmacokinetic studies of 9-(-D-arabinofuranosyl)-6-azidopurine: a prodrug for ara-A designed to utilize the azide reduction pathway.  J. Med. Chem.  1996, 39(26), 5202-5207.
  36. Yang, T.F.; Kim, H.; Kotra, L. P.; Chu, C. K.  Design and synthesis of 2'-hydroxymethyl cyclopropyl carbocyclic nucleosides as potential antiviral agents.  Tetrahedron Lett.  1996, 37(49), 8849-8852.
  37. Koudriakova, T.; Manouilov, K. K.; Shanmuganathan, K.; Kotra, L. P.; Boudinot, F. D.; Sommadossi, J.-P.; Chu, C.K.  In vitro and in vivo evaluation of 6-azido-2',3'-dideoxy-2'-fluoro--D-arabinofuranosylpurine (FAAddP) and N6-methyl-2',3'-dideoxy-2'- fluoro-b-D-arabinofuranosylpurine (FMAddP) as prodrugs of the anti-HIV nucleosides, 2'-F-ara- ddA and 2'-F-ara-ddI.  J. Med. Chem.  1996, 39(23), 4676-4681.
  38. Yang, T. -F.; Kotra, L. P.; Teng, Q.; Naguib, F. N. M.; Sommadossi, J. -P.; el Kouni, M.; Chu, C. K.  Synthesis of [4-hydroxytetrahydrufuran-2-yl] nucleosides as a novel class of uridine phosphorylase inhibitors.  Tetrahedron Lett.  1995, 36(7), 983-986.
  39. Xiang, Y.; Kotra, L. P.; Schinazi, R. F.; Chu, C .K.  Synthesis and anti-HIV activities of 2'-deoxy-2',2''-difluoro-b-L-ribofuranosyl -pyrimidine and -purine nucleosides.  Bioorg. Med. Chem. Lett.  1995, 5(7), 743-748.
  40. Manouilov, K.K.; Fedorov, I.I.; Boudinot, F.D.; White, C.A.; Kotra, L. P.; Schinazi, R.F.; Hong II, C.; Chu, C.K.  Lymphatic targeting of anti-HIV nucleosides: Distribution of 3'-azido-3'-deoxythymidine (AZT) and 3'-azido-2',3'-dideoxyuridine (AZdU) after administration of dipalmitoylphosphatidyl prodrugs to mice.  Antiviral Chem. Chemother.  1995, 6(4), 230-238.
  41. Ray, S.K.; Premakanth, K.L.; Chandrasekar, R. et al. Design of potent antifungal cinnamic acid derivatives: A comparative multiparametric QSAR study involving newly developed electronic parameters, residual information flow (RIF) and residual electronic force (REF).  Med. Sci. Res. (Oxford, UK) 1991, 19, 759-763.

 

Book Chapters and Reviews

 

  1. Majumder, K.; Wei, L.; Annedi, S. C.; Kotra, L. P.  Aminoglycoside antibiotics. In:  Resistance to Antibiotics:  Enzyme-mediated mechanisms and prospects for Inhibition (Marcelo Tolmasky and Robert A. Bonomo, Eds.), ASM Press, 2007, pp. 7-20.
  2. Wang, M.; Hampson, D. R.; Kotra, L. P.  In silico molecular homology modeling of neurotransmitter receptors.  In:  Handbook of Neurochemistry, 2004.
  3. Kotra, L. P.; Hant, P.. Mycobacterium leprae Infections. In: discoverygate: xPharm Version 1.0 SP2 (edited by Sam J. Enna and David B. Bylund) Elsevier, Inc. and MDL Information Systems,Inc., 2004.
  4. Kotra, L. P.; Dixit, P.  Adrenomedullary tumors. In: discoverygate: xPharm  (edited by S.J. Enna and David B. Bylund) Elsevier, Inc. and MDL Information Systems, Inc. Version 1.0 SP2, 2004. (http://www.xpharm.com/)
  5. Kotra, L. P.; Dixit, P.  Calymmatobacterium Granulomatis Infections. In: xPharm-Pharmacological Reference Database  (edited by S.J. Enna and David B. Bylund) Elsevier, Inc., 2004. (http://www.xpharm.com/)
  6. Kotra, L. P.; Dixit, P.  Cestode disease. In: xPharm-Pharmacological Reference Database  (edited by S.J. Enna and David B. Bylund) Elsevier, Inc., 2003. (http://www.xpharm.com/)
  7. Kotra, L. P.; Dixit, P.  Multiple endocrine neoplasias. In: xPharm-Pharmacological Reference Database  (edited by S.J. Enna and David B. Bylund) Elsevier, Inc., 2003. (http://www.xpharm.com/)
  8. Kotra, L. P.; Dixit, P.; Weekes, C. C.  Poxvirus infections. In: xPharm-Pharmacological Reference Database  (edited by S.J. Enna and David B. Bylund) Elsevier, Inc., 2003. (http://www.xpharm.com/)
  9. Kotra, L. P.; Weekes, C. C.  Vibrio infections. In: xPharm-Pharmacological Reference Database  (edited by S.J. Enna and David B. Bylund) Elsevier, Inc., 2003. (http://www.xpharm.com/)
  10. Kotra, L. P.; Weekes, C. C.  Viral encephalitis. In: xPharm-Pharmacological Reference Database  (edited by S.J. Enna and David B. Bylund) Elsevier, Inc., 2003. (http://www.xpharm.com/)
  11. Golemi, D.; Maveyraud, L.; Haddad, J.; Lee, W.; Ishiwata, A.; Miyashita, K.; Mourey, L.; Vakulenko, S.; Kotra, L. P.; Samama, J. P.; Mobashery, S.  Antibacterials as Wonder Drugs and How Their Effectiveness Is Being Compromised.  In:  Trends in Drug Research III (Editor: van der Goot, H.), Pharmacochemistry Library, Vol. 32, 2002, Elsevier Science, pp193-205.
  12. Kotra, L. P.; Samama, J.P.; Mobashery, S.  b-Lactamases and resistance to -lactam antibiotics. In:  Bacterial Resistance to Antimicrobials:  Mechanisms, Genetics, Medical Practice and Public Health.  (Editors:  Wax, Lewis, Salyers, and Taber)  Marcel Dekker, Inc., New York, NY, 2001.
  13. Haddad, J.; Kotra, L. P.; Mobashery, S.  Aminoglycoside antibiotics:  Structures and Mechanisms of Action.  In:  Glycochemistry:  Principles, Synthesis and Applications.  (Editors:  G. P. Wang, and C. R. Bertozzi), Marcel Dekker, Inc., New York, NY, 2001.
  14. Annedi, S. C.; Kotra, L. P.*  RU-79115 (Aventis Pharma AG/Hoechst Marion Roussel).  Curr. Opin. Invest. Antiinfect. Drugs  2001, 2 (6), 752-754.
  15. Kotra, L. P.; Mobashery, S.  A Renascence of Interest in Aminoglycoside Antibiotics. Curr. Org. Chem.  2001, 5, 193-205 (Review Article).
  16. Kotra, L. P.; Haddad, J.; Mobashery, S.  Aminoglycoside Antibiotics: Perspectives on the Mechanisms of Action, Resistance and Strategies to counter resistance.  Antimicrob. Agents Chemother.  2000, 44, 3249-3256 (Review article).
  17. Kotra, L. P.; Amro, N. A.; Liu, G.Y.; Mobashery, S.  Visualizing bacteria at high resolution.  American Society of Microbiology News, 2000, 66 (11), 675-681.
  18. Kotra, L. P.*  Daptomycin. Curr. Opin. Invest. Antiinfect. Drugs  2000, 2, 185-205.
  19. Kotra, L. P.; Golemi, D.; Vakulenko, S.; Mobashery, S.  Antibiotics:  Wonderful pharmaceuticals—How they are being compromized, and what there is to do.  Chem. Industry  May 22, 2000, 339-341.
  20. Kotra, L. P.*  PMX-622. Curr. Opin. Invest. Antiinfect. Drugs  2000, 2, 206-208.
  21. Kotra, L. P.*  Clinafloxacin.  Curr. Opin. Invest. Antiinfect. Drugs  1999, 1, 463-477.
  22. Kotra, L. P., Ojcius, D. M.  Infectious Web-6.  Microbes Infect.  2000, 2, 721.
  23. Kotra, L. P., Ojcius, D. M.  Infectious Web-4.  Microbes Infect.  2000, 2, pp.
  24. Kotra, L. P.,* Ojcius, D. M.  Infectious Web-2.  Microbes Infect.  2000, 2, 231.
  25. Kotra, L. P.,* Ojcius, D. M.  Infectious Web-1.  Microbes Infect.  2000, 2, 99-100.
  26. Kotra, L. P.,* Ojcius, D. M.  Infectious Web-14.  Microbes Infect.  1999, 1 (14), 1239.
  27. Kotra, L. P.,* Ojcius, D. M.  Infectious Web-13.  Microbes Infect.  1999, 1 (13), 1145.
  28. Kotra, L. P., Ojcius, D. M.  Infectious Web-10.  Microbes Infect.  1999, 1 (10), 827.
  29. Kotra, L. P.,* Ojcius, D. M.  Infectious Web-9.  Microbes Infect.  1999, 1 (9), 737-738.
  30. Kotra, L. P.,* Ojcius, D. M.  Infectious Web-8.  Microbes Infect.  1999, 1 (8), 645-646.
  31. Kotra, L. P.; Mobashery, S.  -Lactam antibiotics, b-lactamases, and bacterial resistance. Bull. Inst. Pasteur 1998, 96, 139-150 (Review Article).
  32. Massova, I.; Kotra, L. P.; Fridman, R.; Mobashery, S.  Matrix Metalloproteases: Structures, Evolution and Diversification.  FASEB J.  1998, 12, 1075-1095

 

 

 Last updated:  Jan 24, 2008.