318 Stone Building
P.O. Box 26170
University of North Carolina at Greensboro
Greensboro, NC 27402-6170
Phone (336) 334-5313 • Fax (336) 334-4129
e-mail: mark_failla@uncg.edu
B.S. Chemistry, St. Francis College, Brooklyn,
NY, 1970
M.S. Microbiology, Indiana University, Bloomington,
IN, 1975
Ph.D. Microbiology, Indiana University,1976
R E S E A R C H I N T E R E S T S
Metabolism and functions of essential trace metals, especially in the immune
system; bioavailability and absorption of micronutrients and phytochemicals.
C U R R E N T R E S E A R C H
Role of copper in immunocompetence with emphasis on T cell activation and
macrophage function; regulation of iron absorption using the Caco-2 human
intestinal cell line as a model system; digestion and absorption of
carotenoids and lipophilic vitamins.
R E C E N T P U B L I C A T I O N S
Han, O., Failla, M.L., Hill, A.D., Morris, E.R. and Smith, J.C., Jr. Reduction
of Fe(III) is required for uptake of non-heme iron by Caco-2 cells, J.
Nutrition 125: 1291-1299, 1995.
Hopkins, R.G. and Failla, M.L. Chronic intake of a marginally low copper
diet impairs lymphocyte and neutrophil function in male rats despite minimal
impact on conventional indices of copper status. J. Nutrition 125:
2658-2668, 1995.
Pan, Y., Katula, K. and Failla, M.L. Expression of ceruloplasmin gene in
human and rat lymphocytes. Biochem. Biophys. Acta. 1307: 233-238,
1996.
Martin, K.R., Failla, M.L. and Smith, Jr., J.C. beta-carotene and lutein
protect HepG2 human liver cells against oxidant-induced damage. J. Nutr.
126: 2098-2106, 1996.
Hopkins, R.G. and Failla, M.L. Copper deficiency decreases interleukin-2
production and IL-2 mRNA in human T-lymphocytes. J. Nutrition 127:
257-262, 1997.
Martin, K.R., Loo, G., and Failla, M.L. Human lipoproteins as a vehicle for
the delivery of beta-carotene and alpha-tocopherol to HepG2 cells. Proc.
Soc. Exp. Biol. Med. 214: 367-373, 1997.
Han, O., Failla, M.L., and Smith, Jr., J.C. Transferrin-iron and proinflammatory
cytokines modulate ferritin content and iron transport by Caco-2 cells. J.
Nutritional Biochemistry 8: 585-591, 1997.
Failla, M.L., and Hopkins, R.G. Is low copper status immunosuppressive?
Nutr. Rev. 56: 559-564, 1998.
Pan, Y. and Failla, M.L. Differential up-regulation of ceruloplasmin gene
expression in rat immune tissues during experimental inflammation. Nutr.
Res. 18: 273-282, 1998.
Copyright©1997
The University of North Carolina
at Greensboro
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