Interdisciplinary Statistics and Combinatorics
(October 12-14, 2007)
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Workshop on Dose-Finding Methods in Drug Development It will be a 3-hour workshop to be offered by Dr Stephan Ogenstad, Statogen Consulting, Wake Forest, NC, USA (email: sogenstad@Statogen-Consulting.com) on October 12. Workshop Description: Dose-finding methods aim at coming up with safe and effective drug administration in humans. One of the fundamental objectives in drug development is to find a dose, or dose range, of a drug candidate that is both efficacious and safe in a relative risk-benefit ratio framework. Dose-finding experiments mark out the safe amount of a drug in development, in terms of the quantity given to a patient. Statistical methods play a crucial role in identifying optimal dosage. These methods can provide reliable results and reduce trial duration and costs. There have been many advances in this field in recent years. With new statistical techniques being developed, it is important that these new techniques are utilized correctly. This workshop reviews the main statistical approaches for dose-finding in phase I/II clinical trials and presents practical guidance on their correct use. |
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