Department of Nutrition
Lynda M. Brown, Ph.D.
Assistant Professor
Office: 336-256-0320
email: lmbrown6@uncg.edu
Education and Positions
- Assistant Professor, Dept. of Nutrition, University of North Carolina at Greensboro, 2006-present
- Adjunct Assistant Professor, Dept. of Nutrition, University of North Carolina at Greensboro, 2005-2006
- Postdoctoral Fellow, Obesity Research Center, Genome Research Institute, University of Cincinnati College of Medicine, 2003-2006
- Ph.D., Nutrition, University of Maryland, College Park, 2003
Research Interest (For more information)
- Determine the role of estrogen in determining visceral fat as well as the brain's sensitivity to leptin in middle-aged female rats.
- Central leptin/insulin resistance and their importance in the metabolic syndrome.
- Animal models of obesity including Long-Evans rats, fatty Zucker rats and diet-induced obese rats.
- Establish novel techniques to explore the association between aging, estrogen levels and body fat
as female rats end their reproductive capacity (mimicking menopause in women).
Current Research
- The importance of sex hormones in body fat distribution and energy homeostasis.
- The role of sex hormones in central insulin and leptin resistance and increased visceral fat associated with aging.
- Central insulin resistance in animals maintained on low- and high-fat diets.
- The use of novel therapeutic compounds to reveal the cellular mechanisms of central insulin and leptin sensitivity.
Selected Publications
- Castonguay TW & LM Brown. Effects of food deprivation, starvation and exercise on dietary selection in the rat. In: HR Berthoud & RJ Seeley (eds.) Metabolically Driven Changes in Macronutrient Selection. CRC Press, Boca Raton, pp 219 - 232, 2000.
- Castonguay TW, S Beaulieu, RL Eskay, N Barden, K Kamara, S Khozin, L Lustberg & LM Brown. The effects of adrenalectomy and aldosterone replacement in transgenic mice expressing antisense RNA to the type-2 glucocorticoid receptor. Physiology and Behavior 77:417-423, 2002.
- Haggans CJ, KS Regan, LM Brown, C Wang, J Krebs-Smith, PM Coates & CA Swanson. Computer access to research on dietary supplements (CARDS), a database of federally funded dietary supplement research. Journal of Nutrition, 135: 1796-1799, 2005.
- Clegg DJ, LM Brown, SC Woods & SC Benoit. Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes, Apr;55(4):978-87, 2006.
- Brown LM, DJ Clegg & SC Woods. Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice. Physiology and Behavior Dec; 89(5):687-691, 2006.
- Brown LM, SC Woods & DJ Clegg. Food intake and plasma ghrelin levels following central ghrelin administration in fatty Zucker rats. Peptides Mar 28(3):612-616, 2007.
- Clegg DJ, LM Brown, CJ Kemp, AD Strader, SC Benoit, SC Woods, M Mangiaracina & N Geary. Estradiol-decrease in the orexigenic potency of ghrelin in female rats. Diabetes Apr;56(4):1051-8, 2007.
- Gotoh K, MD Wortman, SC Benoit, DJ Clegg, LM Brown, D D'Alessio, P Tso, RJ Seeley & SC Woods. Consumption of a high fat diet induces central insulin resistance independent of obesity. Submitted to Endocrinology.
- Brown LM, CT Hansen, AF Huberty & TW Castonguay. Genetic background and adrenalectomy alter Neuropeptide Y5 expression and carcass composition in corpulent rats. Submitted to Physiology and Behavior.