Department of Nutrition
Keith Erikson, Ph.D
Assistant Professor
Office: 336-256-0327
email: kmerikso@uncg.edu
Education
- Research Fellow, Wake Forest University. School of Medicine, 2001-2003
- Ph.D., The Pennsylvania State University, 2000
Research Interest
Effects of abnormal trace element (iron, manganese) metabolism on neurobiological and neurochemical outcomes, using animal models and cell culture.
Current Research
- Mechanisms of manganese neurotoxicity.
- Manganese neurotoxicity on glutamate and GABA biology.
- Iron deficiency-associated manganese accumulation on GABA/dopamine interactions
in the brain.
- Role of dopamine transporter in neuronal manganese uptake.
Grant Funding
- Erikson, K (PI). Neurotoxicology of dietary iron/manganese interactions. (R15) NIEHS, 1/05-12/07.
Selected Publications
- Erikson, K.M., Dorman, D.C., Lash, L.H., Aschner, M. (2007) Manganese Inhalation by Rhesus Monkeys is Associated with Brain Regional Changes in Biomarkers of Neurotoxicity. Tox Sci. 97:459-466.
- Erikson, K.M., Thompson, K., Aschner, J., and Aschner, M. (2007) Manganese Neurotoxicity: A Focus on the Neonate. Pharmacol and Therap. 113:369-377.
- Anderson, J.G., Cooney, P.T., Erikson, K.M. (2007) Brain Manganese Accumulation is Inversely Related to GABA Uptake in Male and Female Rats. Toxicol. Sci.95: 188-195.
- Anderson, J.G., Cooney, P.T., Erikson, K.M. (2007) Inhibition of DAT function attenuates manganese accumulation in the globus pallidus Environ Tox and Pharmacol 23:179-184.
- Fitsanakis, V.A., Erikson, K.M., Garcia, S.J., Evje, L., Syversen, T., Aschner, M. (2006) Brain Accumulation of depleted uranium in rats following 3 or 6 month treatment with implanted depleted uranium pellets. Biol Trace Elem Res 111: 185-197.
- Taylor, M.D., Erikson, K.M., Dobson, A.W., Fitsanakis, V., Dorman, D.C., and Aschner, M. (2006) Effects of Inhaled Manganese on Biomarkers of Oxidative Stress in the Rat Brain. Neurotoxicology 27:788-797.
- Erikson, K.M., Dorman, D.C., Fitsanakis, V., Lash, L.H., Aschner, M. (2006) Alterations of oxidative stress biomarkers due to In utero and neonatal exposures of airborne manganese. Biol Trace Elem Res 111:199-215
- Dobson, A.W., Lack, A.K., Erikson, K.M., and Aschner, M. (2006) Depleted uranium is not toxic to rat brain endothelial (RBE4) cells. Biol Trace Elem Res 110(1):61-72.
- Fitsanakis, V.A., Au, Catherine, Erikson, K.M., Aschner, M. (2006) The effects of manganese on glutamate, gamma-aminobutyric acid, and dopamine regulation. Neurochem Intl. 48(6-7):426-433.
- Erikson, K.M., and Aschner, M. (2006) Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter. Neurotoxicology 27:125-130.
- Erikson, K.M., John, C.E., Jones, S.R., Aschner, M. (2005) Manganese accumulation in striatum of mice exposed to toxic doses is dependent upon a functional dopamine transporter. Environ Toxicol Pharmacol. 20:390-394.
- Erikson, K.M., Dorman, D.C., Lash, L., Aschner, M. (2005) Persistent alterations in biomarkers of oxidative stress due to combined in utero and neonatal manganese inhalation. Biol Trace Elem Res. 104(2):151-164.
- Erikson, K.M., Syversen, T., Aschner, J.L., and Aschner M. (2005) Interactions between excessive manganese-exposure and dietary iron-deficiency in neurodegeneration. Environ. Toxicol. Pharmacol. 19:415-421.
- Aschner, M., Erikson, K.M., and Dorman, D.C. (2005) A Review of Manganese Toxicokinetics. Critical Reviews in Toxicology. 35:1-32.
- Erikson, K.M., Dobson, A.W., Dorman, D.C., and Aschner, M. (2004) Does Manganese Induce Oxidative Stress in the Rat Brain? Science and the Total Environment. 334-335:409-416.
- Erikson, K.M., Dorman, D.C., Lash, L.H., Dobson, A.W., and Aschner, M. (2004) Airborne manganese exposure differentially affects endpoints of oxidative stress in an age and sex-dependent manner J Biol Trace Elem. 100:49-62.
- Erikson, K.M., Syversen, T., Steinnes, E., and Aschner, M. (2004) Globus Pallidus: A target brain region for divalent metal accumulation due to dietary iron deficiency. J Nutr Biochem 15:335-341.