Department of Nutrition
Keith Erikson, Ph.D
Associate Professor and Director of Graduate Studies
Office: 336-256-0327
email: kmerikso@uncg.edu
Education
- Research Fellow, Wake Forest University. School of Medicine, 2001-2003
- Ph.D., The Pennsylvania State University, 2000
Research Interest
Effects of abnormal trace element (iron, manganese) metabolism on neurobiological and neurochemical outcomes, using animal models and cell culture.
Current Research
- Mechanisms of manganese neurotoxicity.
- Manganese neurotoxicity on glutamate and GABA biology.
- Iron deficiency-associated manganese accumulation on GABA/dopamine interactions
in the brain.
- Role of dopamine transporter in neuronal manganese uptake.
Grant Funding
- Erikson, K (PI). Mechanisms of Manganese Neurotoxicity: Link between lipid peroxidation and glutathione depletion. (R15) NINDS, 12/07-11/10.
Selected Publications
Williams, B.B., Vadodaria, B.K., Anderson, J.G., Kwakye, G.F., Li, D., Aschner, M., Erikson, K.M., Bowman, A.B. (2009) Altered Manganese Homeostasis in Huntington’s Disease. J Neurochem (in press).
Aschner, M., Erikson, K.M., Herrorro Hernandez, E., Tjalkens, R. (2009) Manganese and its Role in Parkinson's disease: from Transport to Neuropathology. NeuroMolecular Med; ePub Aug 2006.
Messer, J.G., Kilbarger, A.K., Erikson, K.M., Kipp, D.E. (2009) Iron overload alters iron-regulatory genes and proteins, down-regulates osteoblastic phenotype, and is associated with apoptosis in fetal rat calvaria cultures. Bone; ePub July 27.
Anderson, J.G., Fordahl, S.C., Cooney, P.T., Weaver, T.L., Colyer, C.L., and Erikson, K.M. (2009) Extracellular Norepinephrine, Norepinephrine Receptor and Transporter Protein and mRNA Levels Are Differentially Altered in the Developing Rat Brain Due to Dietary Iron Deficiency and Manganese Exposure. Brain Res 1281:1-14.
Fitsanakis, V.A., Thompson, K.N., Deery, S.E., Milatovic, D., Shihabi, Z.K, Erikson, K.M., Brown, R.W., Aschner, M. (2009) A chronic iron deficient/high-manganese diet in rodents results in increased brain oxidative stress and behavioral deficits in the morris water maze. Neurotox Res 15:167-178.
Carneiro, A.M., Airey, D.C., Thompson, B., Zhu, C.B., Lu, L., Chesler, E.J., Erikson, K.M., Blakely, R.D. (2009) Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes. Proc Natl Acad Sci U.S.A. 106:2047-2052.
Zhang, N., Fitsanakis, V.A., Erikson, K.M., Aschner, M., Avison, M.J., Gore, J.C. (2009) A Model for the Analysis of Competitive Relaxation Effects of Manganese and Iron in Vivo. NMR in Biomedicine 22:391-404.
Anderson, J.G., Fordahl, S.C., Cooney, P.T., Weaver, T.L., Colyer, C.L., and Erikson, K.M. (2008) Manganese exposure alters extracellular GABA, GABA receptor and transporter protein and mRNA levels in the developing rat brain. Neurotoxicology Nov;29(6):1044-53.