Department of Nutrition

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    1. Lynda Brown, Ph.D.
    2. Keith Erikson, Ph.D.
    3. Lauren Haldeman, Ph.D.
    4. Deborah E. Kipp, Ph.D., R.D.
    5. George Loo, Ph.D.
    6. Cheryl Ann Lovelady, Ph.D., R.D.
    7. Michael K. McIntosh, Ph.D., R.D.
    8. Ron F. Morrison, Ph.D.
    9. Suzanne E. Rhodes, M.S.
    10. Margaret R. Savoca, Ph.D.
    11. Amy Strickland, M.S., R.D.
    12. Martha L. Taylor-Hawkins, Ph.D., R.D.
    13. Rosemary C. Wander, Ph.D.
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  15. HES

Keith Erikson, Ph.D

Assistant Professor
Office: 336-256-0327
email: kmerikso@uncg.edu

Education

- Research Fellow, Wake Forest University. School of Medicine, 2001-2003
- Ph.D., The Pennsylvania State University, 2000

Research Interest

Effects of abnormal trace element (iron, manganese) metabolism on neurobiological and neurochemical outcomes, using animal models and cell culture.

Current Research

- Mechanisms of manganese neurotoxicity.

- Manganese neurotoxicity on glutamate and GABA biology.
- Iron deficiency-associated manganese accumulation on GABA/dopamine interactions in the brain.
- Role of dopamine transporter in neuronal manganese uptake.

Grant Funding

- Erikson, K (PI). Neurotoxicology of dietary iron/manganese interactions. (R15) NIEHS, 1/05-12/07.

Selected Publications

- Erikson, K.M., Dorman, D.C., Lash, L.H., Aschner, M. (2007) Manganese Inhalation by Rhesus Monkeys is Associated with Brain Regional Changes in Biomarkers of Neurotoxicity. Tox Sci. 97:459-466.

- Erikson, K.M., Thompson, K., Aschner, J., and Aschner, M. (2007) Manganese Neurotoxicity: A Focus on the Neonate. Pharmacol and Therap. 113:369-377.

- Anderson, J.G., Cooney, P.T., Erikson, K.M. (2007) Brain Manganese Accumulation is Inversely Related to GABA Uptake in Male and Female Rats. Toxicol. Sci.95: 188-195.

- Anderson, J.G., Cooney, P.T., Erikson, K.M. (2007) Inhibition of DAT function attenuates manganese accumulation in the globus pallidus Environ Tox and Pharmacol 23:179-184.

- Fitsanakis, V.A., Erikson, K.M., Garcia, S.J., Evje, L., Syversen, T., Aschner, M. (2006) Brain Accumulation of depleted uranium in rats following 3 or 6 month treatment with implanted depleted uranium pellets. Biol Trace Elem Res 111: 185-197.

- Taylor, M.D., Erikson, K.M., Dobson, A.W., Fitsanakis, V., Dorman, D.C., and Aschner, M. (2006) Effects of Inhaled Manganese on Biomarkers of Oxidative Stress in the Rat Brain. Neurotoxicology 27:788-797.

- Erikson, K.M., Dorman, D.C., Fitsanakis, V., Lash, L.H., Aschner, M. (2006) Alterations of oxidative stress biomarkers due to In utero and neonatal exposures of airborne manganese. Biol Trace Elem Res 111:199-215

- Dobson, A.W., Lack, A.K., Erikson, K.M., and Aschner, M. (2006) Depleted uranium is not toxic to rat brain endothelial (RBE4) cells. Biol Trace Elem Res 110(1):61-72.

- Fitsanakis, V.A., Au, Catherine, Erikson, K.M., Aschner, M. (2006) The effects of manganese on glutamate, gamma-aminobutyric acid, and dopamine regulation. Neurochem Intl. 48(6-7):426-433.

- Erikson, K.M., and Aschner, M. (2006) Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter. Neurotoxicology 27:125-130.

- Erikson, K.M., John, C.E., Jones, S.R., Aschner, M. (2005) Manganese accumulation in striatum of mice exposed to toxic doses is dependent upon a functional dopamine transporter. Environ Toxicol Pharmacol. 20:390-394.

- Erikson, K.M., Dorman, D.C., Lash, L., Aschner, M. (2005) Persistent alterations in biomarkers of oxidative stress due to combined in utero and neonatal manganese inhalation. Biol Trace Elem Res. 104(2):151-164.

- Erikson, K.M., Syversen, T., Aschner, J.L., and Aschner M. (2005) Interactions between excessive manganese-exposure and dietary iron-deficiency in neurodegeneration. Environ. Toxicol. Pharmacol. 19:415-421.

- Aschner, M., Erikson, K.M., and Dorman, D.C. (2005) A Review of Manganese Toxicokinetics. Critical Reviews in Toxicology. 35:1-32.

- Erikson, K.M., Dobson, A.W., Dorman, D.C., and Aschner, M. (2004) Does Manganese Induce Oxidative Stress in the Rat Brain? Science and the Total Environment. 334-335:409-416.

- Erikson, K.M., Dorman, D.C., Lash, L.H., Dobson, A.W., and Aschner, M. (2004) Airborne manganese exposure differentially affects endpoints of oxidative stress in an age and sex-dependent manner J Biol Trace Elem. 100:49-62.

- Erikson, K.M., Syversen, T., Steinnes, E., and Aschner, M. (2004) Globus Pallidus: A target brain region for divalent metal accumulation due to dietary iron deficiency. J Nutr Biochem 15:335-341.

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Page updated: 11-Sep-2007

Accessibility Policy

Department of Nutrition
The University of North Carolina at Greensboro
PO Box 26170
Greensboro, NC 27402-6170
VOICE 336.334.5313
EMAIL nutrition@uncg.edu