Department of Nutrition
Wei Jia, Ph.D.
Professor and Co-Director of the UNCG Center for Research Excellence in Bioative Food Components
Office: 704-250-5803
email: w_jia@uncg.edu
Education
- Ph.D., University of Missouri - Columbia, 1996
- M.S., University of Missouri - Columbia, 1991
- B.S., Jiangnan University, 1986
Research Interests
Identification and evaluation of bioactive ingredients from foods, plants, and traditional Chinese medicines for the prevention and treatment of metabolic disorders.
Metabolomic study of disorders including diabetes, obesity, stress, and colorectal cancer is performed to understand:
- how the metabolic profiles of these diseases differ from those of healthy individuals;
- how some important metabolic pathways, such as TCA cycles, homocysteine, gut microbiota - host interactions, alter in response to environmental stimuli or genetic modification;
- how bioactive phytochemical compounds, either alone or in combination, interact with these metabolic pathways to restore the homeostasis of the disturbed metabolic regulatory network.
Selected Recent Publications
- Ni, Y., Su, M., Lin, J., Wang, X., Qiu, Y., Zhao, A., Chen, T., Jia, W. (2008) Metabolic profiling reveals disorder of amino acid metabolism in various brain regions from a rat model of chronic unpredictable mild stress, FEBS Lett. 582 (17): 2627-2636.
- Shen, Q., Li, X., Qiu, Y., Su, M., Liu, Y., Li, H., Wang, X., Zou, X., Yan, C., Yu, L., Li, S., Wan, C., He, L., Jia, W. (2008) Metabonomic and Metallomic Profiling in the Amniotic Fluid of Malnourished Pregnant Rats, J. Proteome Res. 7(5): 2151-2157.
- Jia, W., Li, H., Zhao, L., Nicholson, J.K. (2008) Gut microbiota: a potential new territory for drug targeting, Nat. Rev. Drug Discov. 7: 123-131.
- Xie, G., Plumb, R., Su, M., Xu, Z., Zhao, A., Qiu, M., Long, X., Liu, Z., Jia, W. (2008) Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research, J. Sep. Sci. 31: 1015-1026.
- Wang, X., Su, M., Qiu, Y., Ni, Y., Zhao, T., Zhou, M., Zhao, A., Yang, S., Jia, W. (2007) Metabolic Regulatory Network Alterations in Response to Acute Cold Stress and Ginsenoside Intervention, J. Proteome Res. 6 (9): 3449-3455.
- Li, H., Ni, Y., Su, M., Qiu, Y., Zhou, M., Qiu, M., Zhao, A., Zhao, L., Jia, W. (2007) Pharmaco-metabonomic phenotying reveals different responses to xenobiotic intervention in rats, J. Proteome Res. 6 (4): 1364-1370.
- Ni, Y., Su, M., Qiu, Y., Chen, M., Liu, Y., Jia, W. (2007) Metabolic profiling using combined GC-MS and LC-MS provides a systems understanding of aristolochic acid-induced nephrotoxicity in rat, FEBS Lett. 581(4): 707-711.
- Tao, X., Wang, X., Jia, W. (2007) Using natural Chinese products for diabetes mellitus drug discovery and development, Expert Opin. Drug Discov. 2 (7): 977-986.
- Chen, M., Su, M., Zhao, L., Cheng, J., Lai, Y., Liu, Y. Jia, W. (2006) Metabonomic Study of Aristolochic Acid Induced Nephrotoxicity in Rats, J. Proteome Res. 5(4): 995-1002.
- Chen, M., Zhao, L., Jia, W. (2005) Metabonomic study on the biochemical profiles of a hydrocortisone induced animal model, J. Proteome Res. 4 (6): 2391-2396.