Department of Nutrition
George Loo, Ph.D.
Professor
Office: 336-334-5313
email: g_loo@uncg.edu
Education
- Ph.D. (Nutrition), University of Tennessee, 1986
- M.S., University of Tennessee, 1980
- B.S., University of Georgia, 1975
Research Interest
- Elucidation of molecular mechanisms of phytochemicals
- Antioxidants and redox regulation of gene
expression
Current Research
- Effects of phytochemicals on signal transduction, transcription factors,
and expression of genes involved in DNA damage/repair, cell cycle arrest,
and apoptosis in various human cancer cell lines.
- Effect of cellular iron status on redox-sensitive
gene expression.
Dr. Loo's laboratory has been identified as a "major contributor” to the apoptosis research field
and also the free radical research field (please visit the two websites listed below).
http://www.caspases.org/showauthor.php?surname=Loo&initials=G
http://www.freeradicalscience.com/showauthor.php?surname=Loo&initials=G
Selected Publications
- Smith, A.F., Longpre, J. and Loo, G. (2011) Inhibition by zinc of deoxycholate-induced apoptosis in HCT-116 cells.; Journal of Cellular Biochemistry.; DOI: 10.1002/jcb.23394; vol 113, 650-657 (2012)
- Longpre, J.M. and Loo, G. (2011) Inhibition of deoxycholate-induced apoptosis in iron-depleted HCT-116 cells.; Apoptosis.; DOI: 10.1007/s10495-011-0655-4 vol 17, 70-78 (2012)- Lai C, Loo G. (2011) Cellular iron depletion weakens induction of heme oxygenase-1 by cadmium.; Int J Biochem Cell Biol 43:88-97.
- Longpre, J.M. and Loo, G. (2008) Protection of human colon epithelial cells against deoxycholate by rottlerin. Apoptosis 13, 1162-1171.
- Longpre, J.M. and Loo, G. (2008) Paradoxical effect of diphenyleneiodonium in inducing DNA damage and apoptosis. Free Rad, Res. 42, 533-543.
- Scott, D.W., Longpre, J.M., Loo, G. (2008) Upregulation of GADD153 by butyrate: involvement of MAPK. DNA and Cell Biol. 27, DOI: 10.1089/dna.2008.0773.
- Scott, D.W. and Loo, G. (2007) Curcumin-Induced GADD153 Upregulation: Modulation by Glutathione. J. Cell. Biochem. 101, 307-320.
- Scott, D.W., Mutamba, S., Hopkins, R.G. and Loo, G. (2005) Increased GADD Gene Expression in Human Colon Epithelial Cells Exposed to Deoxycholate. J. Cell. Physiol. 202, 295-303.
- Scott, D.W. and Loo, G. (2004) Curcumin-Induced GADD153 Gene Upregulation in Human Colon Cancer Cells. Carcinogenesis 25, 2155-2164.
- Pan, Y.-J., Hopkins, R.G., and Loo, G. (2004) Increased GADD153 Gene Expression During Iron Chelation-Induced Apoptosis in Jurkat T-Lymphocytes. Biochim. Biophys. Acta 1691, 41-50.
- Takahashi, K. and Loo, G. (2004) Disruption of Mitochondria during Tocotrienol-Induced Apoptosis in MDA-MB-231 Human Breast Cancer Cells. Biochem. Pharmacol. 67, 315-324.
- Powolny, A., Takahashi, K., Hopkins, R.G., and Loo, G. (2003) Induction of GADD Gene Expression by Phenethylisothiocyanate in Human Colon Adenocarcinoma Cells. J. Cell. Biochem. 90, 1128-1139.
- Loo, G. (2003) Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation (Review). J. Nutr. Biochem. 14, 64-73.
- Kelly, M.R., Xu, J., Alexander, K.E., and Loo, G. (2001) Disparate effects of similar phenolic phytochemicals as inhibitors of oxidative damage to cellular DNA. Mutation Res. 485, 309-318.
- Xu, J. and Loo, G. (2001) Different effects of genistein on molecular markers related to apoptosis in phenotypically dissimilar breast cancer cells. J. Cell. Biochem. 82, 78-88.
- Kelly, M.R., Geigerman, C.M., and Loo, G. (2001) Epigallocatechin gallate protects U937 cells against nitric oxide-induced cell cycle arrest and apoptosis. J. Cell. Biochem. 81, 647-658.