Department of Nutrition

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    1. Lynda Brown, Ph.D.
    2. Jigna M. Dharod, Ph.D.
    3. Keith Erikson, Ph.D.
    4. Lauren Haldeman, Ph.D.
    5. Babbi Hawkins, M.S., R.D., L.D.N.
    6. Wei Jia, Ph.D.
    7. Deborah E. Kipp, Ph.D., R.D.
    8. George Loo, Ph.D.
    9. Cheryl Ann Lovelady, Ph.D., R.D.
    10. Michael K. McIntosh, Ph.D., R.D.
    11. Ron F. Morrison, Ph.D.
    12. B. Burgin Ross, M.S., R.D., L.D.N.
    13. Margaret R. Savoca, Ph.D.
    14. Amy Strickland, M.B.A., M.S., R.D.
    15. Martha L. Taylor, Ph.D., R.D.
    16. Zhanxiang Zhou, Ph.D.
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    1. The Nutrition Club
    2. Nutrition Graduate Student Association
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Michael Kenneth McIntosh, Ph.D., R.D., L.S.

Keker Excellence Professor
336/256-0325; Emailmkmcinto@uncg.edu

Curriculum Vitae

Education

- Ph.D., University of Georgia, 1987
- M.S., University of Alberta, 1983

Research Interest

- Obesity and Type 2 Diabetes:
- How does increased adiposity promote inflammation and insulin resistance?
- What role do (pre)adipocytes, macrophages, and myotubes play in mediating inflammation and insulin resistance associated with obesity?
- Nutritional Regulation of Human Adipocytes and Cross-talk with Macrophages:
- How do saturated or trans fatty acids impact adipocyte gene/protein expression and metabolism, signaling, and insulin sensitivity?
- Mechanism(s) by which grape or wine powder extract or their bioactive components prevent inflammation and insulin resistance?

Current Research

(using macrophages, adipocytes, and myotubes as cell models)
- Anti-obesity mechanism of CLA isomer.
- Anti-inflammatory role of bioactive components found in grapes and wine.
- Pro-inflammatory capacity of cells isolated from human adipose tissue.

Recent Publications

(*= graduate students, # = undergraduate students)

Bumrungpert, A,* Kalpravidh, R., Chuang, C.*, Overman, A., Martinez, K., West, T., Kennedy, A.*, McIntosh, M. 2010. Xanthones from Mangosteen Inhibit Inflammation of Human Macrophages and in Human Adipocytes Exposed to Macrophage-conditioned Media. J. Nutr. 140: 842-847.

Overman, A.*, Bumrungpert, K.*, Kennedy, A.*, Martinez, K*. Chuang, C.*, West, T., Jia, W. McIntosh , M. 2010. Polyphenol-rich grape extract attenuates inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. Int. J. Obesity 34: 800-808.

Kennedy, A.*, Martinez, K.*, Schmidt, S.*, Mandrup, S., Lapoint, K. McIntosh, M. 2010. Anti-obesity Mechanisms of Action of Conjugated Linoleic Acid. J. Nutr. Biochem. 21: 171-179.

Kennedy, A.*, Martinez, K.*, Chung, S.*, LaPoint, K. West, T., Hopkins, R, Schmidt, S.*, Andersen,K., Mandrup, S., McIntosh, M. 2010. Inflammation and Insulin Resistance Induced by Trans-10, Cis-12 Conjugated Linoleic Acid are Dependent on Intracellular Calcium Levels in Primary Cultures of Human Adipocytes. J. Lipid Research 51: 1906-1917.

Martinez, K.*, Kennedy, A.*, West, T., Milatovic, D., Aschner, M., McIntosh, M. 2010. Trans-10, cis-12 Conjugated Linoleic Acid Promotes Inflammation to a Greater Extent in Human Adipocytes Compared to Preadipocytes. J. Biol. Chem. 285: 17701-17712.

Chuang, C-C. *, Bumrungpert, A.*, Kennedy, A.*, West. T., Dawson. B., McIntosh, M. 2010. Grape Powder Extract Attenuates Tumor Necrosis Factor alpha-Mediated Inflammation and Insulin Resistance in Primary Cultures of Human Adipocytes J. Nutr. Biochem. 22: 89-94.

Chuang, C-C.*, Martinez, K.*, Xie, G., Kennedy, A.*, Bumrungpert, A.*, Overman, A.*, Jia, W., McIntosh, M. 2010. Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor alpha-mediated inflammation and insulin resistance in primary human adipocytes. Am. J. Clin. Nutr. 92: 1511-1522.