Department of Nutrition

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  8. Dietetic Internship
  9. Faculty
    1. Lynda Brown, Ph.D.
    2. Jigna M. Dharod, Ph.D.
    3. Keith Erikson, Ph.D.
    4. Lauren Haldeman, Ph.D.
    5. Wei Jia, Ph.D.
    6. Deborah E. Kipp, Ph.D., R.D.
    7. George Loo, Ph.D.
    8. Cheryl Ann Lovelady, Ph.D., R.D.
    9. Michael K. McIntosh, Ph.D., R.D.
    10. Ron F. Morrison, Ph.D.
    11. Margaret R. Savoca, Ph.D.
    12. Amy Strickland, M.S., R.D.
    13. Martha L. Taylor, Ph.D., R.D.
  10. Research
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    1. The Nutrition Club
    2. Nutrition Graduate Student Association
  12. Career Options
  13. Important Links
  14. Seminar Schedule (pdf file)
  15. Accomplishments (pdf file)
  16. The UNCG Center for Research Excellence in Bioactive Food Components
  17. Employment Opportunities
  18. Vision, Mission, Values, and Goals
  19. HES

Michael Kenneth McIntosh, Ph.D., R.D

L.S. Keker Excellence Professor
Office: 336-256-0325
email: mkmcinto@uncg.edu

Curriculum Vitae

Education

- Ph.D., University of Georgia, 1987
- M.S., University of Alberta, 1983
- B.S., Ohio University, 1973

Research Interests

Obesity and Type 2 Diabetes:
- How does increased adiposity promote inflammation and insulin resistance?
- What role do (pre)adipocytes, macrophages, and myotubes play in mediating inflammation and insulin resistance associated with obesity?

Nutritional Regulation of Human Adipocytes and Cross-talk with Macrophages:
- How do saturated or trans fatty acids impact adipocyte gene/protein expression and metabolism, signaling, and insulin sensitivity?
- Mechanism(s) by which grape powder extract, mangosteen, or their bioactive components prevent inflammation and insulin resistance?

Current Research

(using macrophages, adipocytes, and myotubes as cell models)

- Anti-obesity mechanism of CLA isomer.
- Anti-inflammatory role of bioactive components found in grapes and mangosteen.
- Pro-inflammatory capacity of cells isolated from human adipose tissue.

Recent Publications

- Kennedy, A., Martinez, K. , Schmidt, S. , Mandrup, S., Lapoint, K. McIntosh, M. 2009. Anti-obesity Mechanisms of Action of Conjugated Linoleic Acid. (J. Nutr. Biochem.- in press).

- Bumrungpert, A, Kalpravidh, R., Chitchumroonchokchai, C., Chuang, C., West, T., Kennedy, A., McIntosh, M. 2009. Xanthones from Mangosteen Prevent Lipopolysccharide-Mediated Inflammation and Insulin Resistance in Primary Cultures of Human Adipocytes J. Nutr. 139: 1185-1191.

- Kennedy, A., Overman, A., Martinez, K., LaPoint, K., Hopkins, R., Chuang, C.C., West, T., Bell, D. & McIntosh, M. 2009. Conjugated Linoleic Acid (CLA)-Mediated Inflammation and Insulin Resistance in Human Adipocytes are Attenuated by Resveratrol. J. Lipid Res. 30: 225-232.

- Kennedy, A, Martinez, K., Chuang, C.C., LaPoint, K., & McIntosh, M. 2008. Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue- Mechanisms of action and implications. J. Nutr. 139:1-4.

- Kennedy, A., S. Chung, K. LaPoint, O. Fabiyi, & M. McIntosh. 2008. Trans-10, Cis-12 Conjugated Linoleic Acid Antagonizes Ligand -Dependent PPARgamma Activity in Primary Cultures of Human Adipocytes. J. Nutr. 138: 455-461. (Editors’ Pick of the Month for March ‘08).

- Chung, S., LaPoint, K., Kennedy, A., Martinez, K., Boysen-Sandberg, M., & McIntosh, M. 2006. Preadipocytes mediated LPS-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes. Endocrinology 147: 5340-5351.

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Page updated: 01-Sep-2009

Accessibility Policy

Department of Nutrition
The University of North Carolina at Greensboro
PO Box 26170
Greensboro, NC 27402-6170
VOICE 336.334.5313
EMAIL nutrition@uncg.edu