Department of Nutrition
Michael Kenneth McIntosh, Ph.D., R.D
L.S. Keker Excellence Professor
Office: 336-256-0325
email: mkmcinto@uncg.edu
Education
- Ph.D., University of Georgia, 1987
- M.S., University of Alberta, 1983
- B.S., Ohio University, 1973
- R.D., University of Wisconsin-Stout, 1988
Research Interests
Obesity and Type 2 Diabetes:
- How does increased adiposity promote inflammation and insulin resistance?
- What role do (pre)adipocytes, macrophages, and myocytes play in mediating inflammation and insulin
resistance associated with obesity?
Nutritional Regulation of Human Adipocytes and Cross-talk with
Macrophages:
- How do saturated or trans fatty acids impact adipocyte gene/protein expression and metabolism,
signaling, and insulin sensitivity?
- Mechanism(s) by which grape powder extract, mangosteen, or their bioactive components prevent
inflammation and insulin resistance?
Current Research
(using macrophages, adipocytes, and myotubes as cell models)- Anti-obesity mechanism of CLA isomer.
- Anti-inflammatory role of bioactive components found in grapes and mangosteen.
- Pro-inflammatory capacity of cells isolated from human adipose tissue.
Recent Publications
- Kennedy, A., A. Overman, K. Martinez, K. LaPoint, R. Hopkins, C.C. Chuang, T. West, Bell, D. & M. McIntosh. 2008. Conjugated Linoleic Acid (CLA)-Mediated Inflammation and Insulin Resistance in Human Adipocytes are Attenuated by Resveratrol. J. Lipid Res. (in press).
- Kennedy, A., A. Martinez, C.C. Chuang, K. LaPoint, & M. McIntosh. 2008. Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue- Mechanisms of action and implications. J. Nutr. (in press).
- Kennedy, A., S. Chung, K. LaPoint, O. Fabiyi#, & M. McIntosh. 2008. Trans-10, Cis-12 Conjugated Linoleic Acid Antagonizes Ligand -Dependent PPAR-gamma Activity in Primary Cultures of Human Adipocytes. J. Nutr. 138: 455-461. (Editors’ Pick of the Month for March 2008).
- Chung, S., LaPoint, K., Kennedy, A., Martinez, K., Boysen-Sandberg, M., & McIntosh, M. 2006. Preadipocytes mediated LPS-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes. Endocrinology 147: 5340-5351.
- Chung, S., Brown, J.M., Provo, J., Hopkins, R., & McIntosh, M. 2005. Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production. J. Biol. Chem. 280: 38445-38456.
- Chung, S., Brown, J.M., & McIntosh, M. 2005. Trans-10, cis-12 CLA increases adipocyte lipolysis and alters lipid droplet-associated proteins: role of mTOR and ERK signaling. J. Lipid Res. 46: 885-895.
- Brown, J.M., Boysen, M.S., Chung, S. , Fabiyi, O., Morrision, R., Mandrup, S., & McIntosh, M. 2004. Conjugated linoleic acid (CLA) induces human adipocyte delipidation: autocrine/ paracrine regulation of MEK/ERK signaling by adipocytokines. J. Biol. Chem. 279: 26735-26747.