Michael Kenneth McIntosh, Ph.D., R.D., L.S.
Keker Excellence Professor
336/256-0325; Emailmkmcinto@uncg.edu
Curriculum Vitae
Education
- Ph.D., University of Georgia, 1987
- M.S., University of Alberta, 1983
Research Interest
- Obesity and Type 2 Diabetes:
- How does increased adiposity promote inflammation and insulin resistance?
- What role do (pre)adipocytes, macrophages, and myotubes play in mediating inflammation and insulin resistance associated with obesity?
- Nutritional Regulation of Human Adipocytes and Cross-talk with Macrophages:
- How do saturated or trans fatty acids impact adipocyte gene/protein expression and metabolism, signaling, and insulin sensitivity?
- Mechanism(s) by which grape or wine powder extract or their bioactive components prevent inflammation and insulin resistance?
Current Research
(using macrophages, adipocytes, and myotubes as cell models)
- Anti-obesity mechanism of CLA isomer.
- Anti-inflammatory role of bioactive components found in grapes and wine.
- Pro-inflammatory capacity of cells isolated from human adipose tissue.
Recent Publications
(*= graduate students, # = undergraduate students)
Bumrungpert, A,* Kalpravidh, R., Chuang, C.*, Overman, A., Martinez, K., West, T., Kennedy, A.*, McIntosh, M. 2010. Xanthones from Mangosteen Inhibit Inflammation of Human Macrophages and in Human Adipocytes Exposed to Macrophage-conditioned Media.
J. Nutr. 140: 842-847. Overman, A.
*, Bumrungpert, K.
*, Kennedy, A.
*, Martinez, K*. Chuang, C.*, West, T., Jia, W. McIntosh , M. 2010. Polyphenol-rich grape extract attenuates inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media.
Int. J. Obesity 34: 800-808.
Kennedy, A.*, Martinez, K.*, Schmidt, S.*, Mandrup, S., Lapoint, K. McIntosh, M. 2010. Anti-obesity Mechanisms of Action of Conjugated Linoleic Acid. J. Nutr. Biochem. 21: 171-179.
Kennedy, A.*, Martinez, K.*, Chung, S.*, LaPoint, K. West, T., Hopkins, R, Schmidt, S.*, Andersen,K., Mandrup, S., McIntosh, M. 2010. Inflammation and Insulin Resistance Induced by Trans-10, Cis-12 Conjugated Linoleic Acid are Dependent on Intracellular Calcium Levels in Primary Cultures of Human Adipocytes. J. Lipid Research 51: 1906-1917.
Martinez, K.*, Kennedy, A.*, West, T., Milatovic, D., Aschner, M., McIntosh, M. 2010. Trans-10, cis-12 Conjugated Linoleic Acid Promotes Inflammation to a Greater Extent in Human Adipocytes Compared to Preadipocytes. J. Biol. Chem. 285: 17701-17712.
Chuang, C-C. *, Bumrungpert, A.*, Kennedy, A.*, West. T., Dawson. B., McIntosh, M. 2010. Grape Powder Extract Attenuates Tumor Necrosis Factor alpha-Mediated Inflammation and Insulin Resistance in Primary Cultures of Human Adipocytes J. Nutr. Biochem. 22: 89-94.
Chuang, C-C.*, Martinez, K.*, Xie, G., Kennedy, A.*, Bumrungpert, A.*, Overman, A.*, Jia, W., McIntosh, M. 2010. Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor alpha-mediated inflammation and insulin resistance in primary human adipocytes. Am. J. Clin. Nutr. 92: 1511-1522.