Department of Nutrition
Rosemary C. Wander, Ph.D
Professor
Associate Provost for Research
Office: 336-256-0426
email: rcwander@uncg.edu
Education
- Ph.D., University of Georgia
- M.S., Ohio State University
- B.S., Centenary College
Research Interest
The role of dietary fats, particularly different fatty acids, on cardiovascular health at the cellular and molecular level. Current interests focus on the effects of highly unsaturated fatty acids on oxidative stress, inflammation, immune function, and gene expression as they relate to risk of cardiovascular disease.
Current Research
Current research includes both in vivo and in vitro studies. A clinical trial in postmenopausal women was recently completed. This trial addressed the impact of the consumption of fish oils on cardiovascular risk factors, i.e., the lipid profile, low density lipoprotein oxidative susceptibility, C-reactive protein, and paraoxonase. The in vitro studies address the effect of the n-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid, on inflammatory markers relevant to atherogenesis, i.e., cytokines and C-reactive protein, using various cell types (U937 promonocytes, freshly isolated monocytes, monocyte-derived macrophages, and human aortic endothelial cells).
Selected Publications
- Toobert D.J., Glasgow R.E., Strycker L.A., Barrera M., Radcliffe J.L., Wander R.C., and Bagdade J.D. Biologic and quality-of-life outcomes from the Mediterranean Lifestyle Program: a randomized clinical trial (2003). Diabetes Care. 26:2288-93.
- Hall J.A., Tooley K.A., Gradin J.L., Jewell D.E., and Wander R.C. Effects of dietary n-6 and n-3 fatty acids and vitamin E on the immune response of healthy geriatric dogs (2003). Am J Vet Res. 64:762-72.
- Manns P.J., Williams D.P., Snow C.M., Wander R.C. Physical activity, body fat, and serum C-reactive protein in postmenopausal women with and without hormone replacement.(2003). Am J Human Biol. 15:91-100.
- Ciubotaru I., Lee Y.S., Wander R.C. Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on hormone replacement therapy. (2003). Journal of Nutritional Biochemistry. 14:513-21.
- Wu T., Geigerman C., Lee Y.S., Wander R.C. Enrichment of LDL with EPA and DHA decreased oxidized LDL-induced apoptosis in U937 cells. (2002). Lipids Aug;37:789-96.