Curriculum Vitae
Paul
Anthony Steimle
Assistant Professor
Department
of Biology
312
Eberhart Building,
EDUCATION/TRAINING
Postdoctoral Fellow (Cellular Regulation of Myosin II), 4/1998 to 7/2001
Advisor: Dr. Thomas T. Egelhoff
Department of Physiology and Biophysics
Postdoctoral Fellow (Regulation of Cell Adhesion), 3/1996 to 4/1998
Advisor: Dr. Susan W. Craig
Department of Biological Chemistry
Ph.D. (Regulatory Biology), 3/1996
Advisor: Dr. Edward L. Jarroll
Department of Biology
Dissertation: Biosynthesis
of galactosamine in encysting Giardia.
BS (Biology), 6/1990
RESEARCH FUNDING
National Institutes of
Health
·
Academic Research Enhancement Award (R15) - Link
to grant abstract in CRISP Database
Project
Title: “Cellular Regulation of a Myosin
II Heavy Chain Kinase”
Award
Dates: 10/1/03 to 9/30/06
·
Research Supplement for Underrepresented Minorities
Supplement
to AREA Grant listed above
Award
Dates: 5/16/05 to 9/30/06
National Science
Foundation – Instrumentation Grant Program – Link to
NSF Award Abstract
Project Title: “MRI/RUI-Acquisition of a Confocal Microscope
for Multiple Users at UNCG”
Co-PI with Esther
Leise (PI), Amy Adamson, Mark Hens, Dennis LaJeunesse
Award Dates: 9/1/2003 to 8/31/2006
Previous Grants/Fellowships -
American
Cancer Society Postdoctoral Fellowship 7/99 to 7/01
NIH
Cell Physiology Postdoctoral Fellow (CWRU) – 4/98 to 4/99
Graduate
Student Research Award (Cleveland State U.) – 1991
PROFESSIONAL SERVICE AND ACTIVITIES
Grant Review:
1.
National Institutes of Health – Center for Scientific Review Special Emphasis Panel (ZRG1-MOSSD-04); Muscle
Biology – March 2005.
2.
National Institutes of Health - ad hoc Review of SCORE subproject
proposal – November 2004.
Journal Review (ad hoc):
1. Biochemical
Journal
2. Biochimica
et Biophysica Acta
3. Cellular
and Molecular Life Sciences
4. FEBS
Letters
5. Journal of Biological Chemistry
6. Journal
of Cell Biology
7. Journal of Cellular Physiology
8. Journal
of Eukaryotic Microbiology
9. Molecular
Biology of the Cell
10. Proceedings of the Indian Nat’l Acad.
Sciences
Other Service:
1.
Judge
for Initial Phase of the 2004 Siemens Westinghouse Competition in Math, Science
&Technology – Biology Section.
2.
Judge
for the
Professional Memberships:
1.
American
Society for Cell Biologyy – 1995 to Present
2.
American
Association for the Advancement of Science – 2002 to Present
3.
American
Society for Biochemistry and Molecular Biology – 2004 to Present
4.
International
Society of Protozoologists – 2004 to Present
5.
Council
on Undergraduate Research – 2001 to Present
ACADEMIC SERVICE AND ACTIVITIES
University Committees and Service:
1.
Faculty
Grievance Committee – 2003 to Present
2.
University
Liaison to the Council on Undergraduate Research – 2001 to Present
Departmental Committees and Service:
1.
Biology
Undergraduate Curriculum Committee – 2002 to Present
2.
Biology
Club Faculty Advisor – 2002 to Fall 2004
3.
Biotechnology
Curriculum and Facilities Committee – 2001 to Present
4.
Confocal
Microscope Facility Committee – 2002 to Present
5.
Faculty
Recruitment Search Committee (Invertebrate Biologist) – 2002
6.
Library
Liaison to the Biology Department – 2002 to Present
7.
New
8.
Pre-Health
Professional Undergraduate Advising – 2002 to Present
PUBLICATIONS
1.
Steimle, P.A.,
Fulcher, K.F., Patel, Y.M. (2005) A novel role for myosin II in insulin-stimulated
glucose uptake in 3T3-L1 adipocytes. Biochemical and Biophysical Research
Communications. 331(4): 1560-1565.
2.
Egelhoff,
T.T., Croft, D., Steimle, P.A. (2005) Actin-Activation of Myosin Heavy
Chain Kinase A in Dictyostelium: A
biochemical mechanism for the spatial regulation of myosin II filament
disassembly. Journal of Biological Chemistry. 280:2879 – 2887.
3.
Steimle,
P.A., Licate, L., Côté, G.P., Egelhoff, T.T. (2002)
Lamellipodial localization of Dictyostelium myosin heavy chain kinase A is mediated via F-actin binding by the coiled-coil
domain. FEBS Letters. 516:58-62.
4.
Steimle, P.A.,
Yumura, S., Côté, G.P., Medley, Q.G., Polyakov, M., Leppert, B., Egelhoff, T.T.
(2001) Recruitment of a myosin heavy chain kinase to actin-rich protrusions in Dictyostelium. Current Biology. 11:708-713.
5.
Jarroll,
E.L., Macechko, P.T., Steimle, P.A., Bulik, D., Karr, C.D., van Keulen,
H., Paget, T.A., Gerwig, G., Kamerling, J., Vliegenthart, J., Erlandsen, S.
(2001) Regulation of carbohydrate metabolism during Giardia encystment. Journal
of Eukaryotic Microbiology. 48:22-26.
6.
Luo,
X., Crawley, S.W., Steimle, P.A.,
Egelhoff, T.T., Côté, G. P. (2001) Specific phosphorylation of threonine by the Dictyostelium myosin II heavy chain
kinase family. Journal of Biological Chemistry.
276: 17836-17843.
7.
Steimle, P.A.,
Licate, L., Naismith, T., Egelhoff, T.T. (2000) WD-Repeat domains target Dictyostelium myosin heavy chain kinase activities by binding directly to myosin II. Journal
of Biological Chemistry. 276:6853-6860.
8.
Steimle, P.A.,
Hoffert, J.D., Adey, N.B, Craig, S.W. (1999) Polyphosphoinositides inhibit the interaction of vinculin with actin
filaments. Journal
of Biological Chemistry. 274:18414-18420.
9.
Van
Keulen, H., Steimle, P.A., Boroviak,
R.K., Bulik, D.A., Jarroll, E.L. (1998) Cloning of two putative Giardia lamblia glucosamine 6-phosphate
isomerase genes only one of which is transcriptionally activated during
encystment. Journal of Eukaryotic
Microbiology. 45(6): 637-642.
10.
Jarroll,
E.L., Macechko, P.T., Steimle, P.A.,
Lindmark, D.G., and Erlandsen, S.L. (1994) Enzymes of galactosamine synthesis
in encysting Giardia are induced. In: Giardia: From Molecules to Disease.
(Thompson, A., Reynoldson, J., and Lymbury, A., eds). CAB International,
11.
Steimle, P.A.,
Lindmark, D.E., Jarroll, E.L. (1996) Purification and characterization of
encystment-induced glucosamine 6-phosphate isomerase in Giardia. Molecular and
Biochemical Parasitology. 84:149-153.
12.
Macechko,
P.T., Steimle, P.A., Lindmark, D.G.,
Erlandsen, S.L., Jarroll, E.L. (1992) Galactosamine synthesizing enzymes are
induced when Giardia encyst. Molecular and Biochemical Parasitology.
56:301-310.
Recent
Meeting Abstracts:
1.
D.
Croft, M. Sharp, P. Brake, R. Martinez, P.
Steimle. (2004) Studies of the Actin-Binding and Cellular Translocation
Activities of Myosin Heavy Chain Kinase A from Dictyostelium Reveal a Coiled-Coil Domain with Multiple Functions.
44th Annual Meeting of the American Society for Cell Biology.
December 4 - 8, 2004.
2.
D.
Croft, K. LaPoint, T. T. Egelhoff, P. A.
Steimle. (2003) Dictyostelium Myosin Heavy Chain Kinase A is Activated by a Direct
Interaction with Actin Filaments. 43rd Annual Meeting of the American Society for
Cell Biology. December 13 - 17, 2003.
3.
Croft,
D., Tibaquiara, L.I., Egelhoff, T.T., Steimle, P.A. (2002) Dictyostelium myosin heavy chain
kinase A localizes to actin-rich cortical structures via f-actin binding by its
coiled-coil domain. December 14 - 18,
2002. 41st Annual Meeting of the American Society for Cell Biology.