Curriculum Vitae

 

Paul Anthony Steimle

 

Assistant Professor

Department of Biology

University of North Carolina at Greensboro

312 Eberhart Building, Greensboro , NC 27402

E-mail: p_steiml@uncg.edu

Office: (336) 334-4949       Lab: (336) 256-0409          Fax: (336) 334-5839

 

 

EDUCATION/TRAINING

 

 

Postdoctoral Fellow (Cellular Regulation of Myosin II), 4/1998 to 7/2001

Advisor: Dr. Thomas T. Egelhoff

Department of Physiology and Biophysics

Case Western Reserve University , Cleveland , OH

 

Postdoctoral Fellow (Regulation of Cell Adhesion), 3/1996 to 4/1998

Advisor: Dr. Susan W. Craig

Department of Biological Chemistry

Johns Hopkins University School of Medicine, Baltimore , MD

 

Ph.D. (Regulatory Biology), 3/1996

Advisor: Dr. Edward L. Jarroll

Department of Biology

Cleveland State University , Cleveland , OH

Dissertation:  Biosynthesis of galactosamine in encysting Giardia.

 

BS (Biology), 6/1990

Department of Biology

Cleveland State University , Cleveland , OH

 

 

 

RESEARCH FUNDING

National Institutes of Health

 

·        Academic Research Enhancement Award (R15) - Link to grant abstract in CRISP Database

Project Title:  “Cellular Regulation of a Myosin II Heavy Chain Kinase”

Award Dates:  10/1/03 to 9/30/06

 

·        Research Supplement for Underrepresented Minorities

Supplement to AREA Grant listed above

Award Dates:  5/16/05 to 9/30/06

 

National Science Foundation – Instrumentation Grant Program – Link to NSF Award Abstract

              Project Title:  “MRI/RUI-Acquisition of a Confocal Microscope for Multiple Users at UNCG”

              Co-PI with Esther Leise (PI), Amy Adamson, Mark Hens, Dennis LaJeunesse

              Award Dates:  9/1/2003 to 8/31/2006

 

Previous Grants/Fellowships -

 

American Cancer Society Postdoctoral Fellowship 7/99 to 7/01

 

NIH Cell Physiology Postdoctoral Fellow (CWRU) – 4/98 to 4/99

 

Ohio Academic Challenge Pre-Doctoral Fellow – 1992 to 1996

 

Graduate Student Research Award (Cleveland State U.) – 1991

 

 

PROFESSIONAL SERVICE AND ACTIVITIES

 

Grant Review: 

 

1.      National Institutes of Health – Center for Scientific Review Special Emphasis Panel (ZRG1-MOSSD-04); Muscle Biology – March 2005.

2.      National Institutes of Health - ad hoc Review of SCORE subproject proposal – November 2004.

 

Journal Review (ad hoc):

 

1.  Biochemical Journal

2.  Biochimica et Biophysica Acta                           

3.  Cellular and Molecular Life Sciences                

4.  FEBS Letters

5. Journal of Biological Chemistry

6.  Journal of Cell Biology

7.   Journal of Cellular Physiology

8.  Journal of Eukaryotic Microbiology

9.  Molecular Biology of the Cell

10. Proceedings of the Indian Nat’l Acad. Sciences

 

Other Service:

 

1.      Judge for Initial Phase of the 2004 Siemens Westinghouse Competition in Math, Science &Technology – Biology Section.

2.      Judge for the North Carolina Science Olympiad 2004 and 2005 – Cell Biology Section

 

Professional Memberships:

 

1.      American Society for Cell Biologyy – 1995 to Present

2.      American Association for the Advancement of Science – 2002 to Present

3.      American Society for Biochemistry and Molecular Biology – 2004 to Present

4.      International Society of Protozoologists – 2004 to Present

5.      Council on Undergraduate Research – 2001 to Present

 

 

ACADEMIC SERVICE AND ACTIVITIES

 

University Committees and Service:

 

1.      Faculty Grievance Committee – 2003 to Present

2.      University Liaison to the Council on Undergraduate Research – 2001 to Present

 

Departmental Committees and Service:

 

1.      Biology Undergraduate Curriculum Committee – 2002 to Present

2.      Biology Club Faculty Advisor – 2002 to Fall 2004

3.      Biotechnology Curriculum and Facilities Committee – 2001 to Present

4.      Confocal Microscope Facility Committee – 2002 to Present

5.      Faculty Recruitment Search Committee (Invertebrate Biologist) – 2002

6.      Library Liaison to the Biology Department – 2002 to Present

7.      New Science Building Equipment Committee – 2002

8.      Pre-Health Professional Undergraduate Advising – 2002 to Present

 

 

 

PUBLICATIONS

 

1.      Steimle, P.A., Fulcher, K.F., Patel, Y.M. (2005) A novel role for myosin II in insulin-stimulated glucose uptake in 3T3-L1 adipocytes.  Biochemical and Biophysical Research Communications.  331(4): 1560-1565.

 

2.      Egelhoff, T.T., Croft, D., Steimle, P.A. (2005) Actin-Activation of Myosin Heavy Chain Kinase A in Dictyostelium: A biochemical mechanism for the spatial regulation of myosin II filament disassembly.  Journal of Biological Chemistry. 280:2879 – 2887.  

 

3.      Steimle, P.A., Licate, L., Côté, G.P., Egelhoff, T.T. (2002) Lamellipodial localization of  Dictyostelium myosin heavy chain kinase A is mediated via F-actin binding by the coiled-coil domain. FEBS Letters. 516:58-62.

 

4.      Steimle, P.A., Yumura, S., Côté, G.P., Medley, Q.G., Polyakov, M., Leppert, B., Egelhoff, T.T. (2001) Recruitment of a myosin heavy chain kinase to actin-rich protrusions in Dictyostelium.  Current Biology. 11:708-713.

 

5.      Jarroll, E.L., Macechko, P.T., Steimle, P.A., Bulik, D., Karr, C.D., van Keulen, H., Paget, T.A., Gerwig, G., Kamerling, J., Vliegenthart, J., Erlandsen, S. (2001) Regulation of carbohydrate metabolism during Giardia encystment. Journal of Eukaryotic Microbiology. 48:22-26.

 

6.      Luo, X., Crawley, S.W., Steimle, P.A., Egelhoff, T.T., Côté, G. P. (2001) Specific phosphorylation of threonine by the Dictyostelium myosin II heavy chain kinase family.  Journal of Biological Chemistry. 276: 17836-17843.

 

7.      Steimle, P.A., Licate, L., Naismith, T., Egelhoff, T.T.  (2000) WD-Repeat domains target Dictyostelium myosin heavy chain kinase activities by binding directly to myosin II.  Journal of Biological Chemistry.  276:6853-6860.

 

8.      Steimle, P.A., Hoffert, J.D., Adey, N.B, Craig, S.W. (1999) Polyphosphoinositides inhibit the interaction of vinculin with actin filaments.  Journal of Biological Chemistry. 274:18414-18420.

 

9.      Van Keulen, H., Steimle, P.A., Boroviak, R.K., Bulik, D.A., Jarroll, E.L. (1998) Cloning of two putative Giardia lamblia glucosamine 6-phosphate isomerase genes only one of which is transcriptionally activated during encystment. Journal of Eukaryotic Microbiology. 45(6): 637-642.

 

10.  Jarroll, E.L., Macechko, P.T., Steimle, P.A., Lindmark, D.G., and Erlandsen, S.L. (1994) Enzymes of galactosamine synthesis in encysting Giardia are induced. In: Giardia: From Molecules to Disease. (Thompson, A., Reynoldson, J., and Lymbury, A., eds). CAB International, Oxon , U.K. pp. 198-199.

 

11.  Steimle, P.A., Lindmark, D.E., Jarroll, E.L. (1996) Purification and characterization of encystment-induced glucosamine 6-phosphate isomerase in Giardia. Molecular and Biochemical Parasitology. 84:149-153.

 

12.  Macechko, P.T., Steimle, P.A., Lindmark, D.G., Erlandsen, S.L., Jarroll, E.L. (1992) Galactosamine synthesizing enzymes are induced when Giardia encyst. Molecular and Biochemical Parasitology. 56:301-310.

 

 

Recent Meeting Abstracts:

 

1.      D. Croft, M. Sharp, P. Brake, R. Martinez, P. Steimle. (2004) Studies of the Actin-Binding and Cellular Translocation Activities of Myosin Heavy Chain Kinase A from Dictyostelium Reveal a Coiled-Coil Domain with Multiple Functions. 44th Annual Meeting of the American Society for Cell Biology. December 4 - 8, 2004. Washington , DC . 

 

2.      D. Croft, K. LaPoint, T. T. Egelhoff, P. A. Steimle. (2003)  Dictyostelium Myosin Heavy Chain Kinase A is Activated by a Direct Interaction with Actin Filaments.  43rd  Annual Meeting of the American Society for Cell Biology. December 13 - 17, 2003.

 

3.      Croft, D., Tibaquiara, L.I., Egelhoff, T.T., Steimle, P.A. (2002)  Dictyostelium myosin heavy chain kinase A localizes to actin-rich cortical structures via f-actin binding by its coiled-coil domain.  December 14 - 18, 2002. 41st Annual Meeting of the American Society for Cell Biology. San Francisco , CA .

 

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