Other Affiliations:
Editor, Environmental Epigenetics
Academic Editor, Journal of Xenobiotics
Associate Editor, Epigenetics
Associate Editor, Epigenetics Reports
Editorial Board, Frontiers in Genetics
Education
Ph.D. Physiology. Hokkaido University
Courses Taught
- Developmental Biology
- Human Embryology and Teratology
- Reproductive Biology
- Concepts in Biological Sciences
Research
Epigenetic modifications control how genetic information is expressed without altering genetic codes stored in DNA. Environmental exposures can positively or negatively influence epigenetic modifications, leading to alterations in physiological functions. Some alterations can be passed down to subsequent generations through non-genetic inheritance. My laboratory is located at the University of Missouri . We study gene-environment interactions, particularly how environmental stressors (chemical or non-chemical) induce epigenetic changes leading to adverse health outcomes. In research, we utilize animal models (fish and rodents), cell co-cultures (2D and 3D spheroids), human cell lines, and population-based studies.
Selected Publications
Chakraborty, S., Anand, S., Numan, M., Bhandari, R.K. (2023). Ancestral bisphenol A exposure led to nonalcoholic fatty liver disease and sex-specific alterations in proline and bile metabolism pathways in the liver. Environmental Toxicology and Chemistry. Vgae081.
Coe, S.,Chakraborty, S.,Faheem, M.,Kupradit, K., Bhandari, R.K. (2024). A second hit by PFOS exposure exacerbated developmental defects in medaka embryos with a history of ancestral BPA exposure. Chemosphere, 362: 142796
Doldron, M.,Chakraborty, S., Anand, S., ‡Faheem, M., Reh, B., Wang, X., Mallik, S., Jia, Z., Bhandari, R. K. Transcriptional Alterations in Human Bronchial Epithelial Cells Associated with Delta-9-Tetrahydrocannabinol Cytotoxicity: Involvement of Ferroptosis Pathway. Preprints 2024, 2024060598
Chakraborty S, Anand S, Bhandari RK. Sex-specific expression of the human NAFLD-NASH transcriptional signatures in the medaka liver with a history of ancestral bisphenol A exposure. bioRxiv. 2024:2024.05.19.594843.
Wang, X., Bhandari, R.K. (2024). Methylome profile of medaka eggs and sperm. Epigenetics, 19(1): 2417151.
Chakraborty, S., Anand, S., Coe, S.T.,Reh, B., Bhandari, R.K. (2023). The PCOS–NAFLD Multi-disease phenotype occurred in medaka fish four generations after the removal of bisphenol A exposure. Environmental Science and Technology 57 (34), 12602-12619.
Chakraborty, S., Dissanayake, M., Godwin, J., Wang, X., Bhandari, R.K. (2023). Ancestral BPA exposure caused defects in the liver of medaka for four generations. Science of the Total Environment.856 (1):159067.
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