| J. Phillip Bowen |
 |
Title |
Professor and Director of the Center for Drug Discovery |
| Expertise |
Computational, medicinal, and organic chemistry |
| Education |
- B.S., Piedmont College, 1979
- Ph.D., Emory University, 1984
- Postdoctoral Fellow, University of Georgia, 1984-1986
|
| Office |
Sullivan Science Building, Rm 400 |
| Phone |
336.334.4257 |
| E-Mail |
Email Dr. Bowen |
| Group Website |
http://drugdesign.uncg.edu |
|
Zhong, H.; Lee, M.; Bowen, J. P. “Modeling and Simulations of Nucleic Acids and Their Complexes.” In Synthetic and Biophysical Studies of DNA Binding Compounds. 2008 (in press).
Zhong, H.; Bowen, J. P. “Binding Free Energy Calculation for Duocarmycin/DNA Complex Based on the QPLD-Derived Partial Charge Model.” Bioorganic & Medicinal Chemistry Letters 2007 (accepted).
Zhong, H.; Bowen, J. P. “Molecular Design and Clinical Development of VEGF Kinase Inhibitors.” Current Topics in Medicinal Chemistry 2007, 7,1379-1393.
Bowen, J. P.; Sorensen, J. B.; Kirschner, K. N. “Calculating Interaction Energies Using First Principle Theories – Consideration of Basis Set Superposition Error and Gragment Relazation.” J. Chem. Educ. 2007, 84, 1225-1229.
Arbiser, J. L. ; Kau, T.; Konar, M.; Narra, K.; Ramchandran, R.; Summers, S. A.; Vlahos, C. J.; Ye, K.; Perry, B. N.; Matter, W.; Fischl, A.; Cook, J.; Silver, P. A.; Bain, J.; Cohen, P.; Whitmire, D.; Furness, S.; Govindarajan, B.; Bowen, J. P. “Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositl-3-kinase signaling and angiogenesis.” Blood 2007, 109, 560-565.
Zhong, H.; Bowen, J. P. “Antiangiogenesis Drug Design: Multiple Pathways Targeting Tumor Vasculature.” Curr. Med. Chem. 2006, 13, 849-862.
Furness, M. S.; Robinson, T. P.; Ehlers, T.; Hubbard, IV, R. B.; Arbiser, J. L.; Goldsmith, D.; Bowen, J. P.; “Antiangiogenic Agents: Studies of Fumagillin and Curcumin Analogs.” Current Pharmaceutical Design 2005, 111, 357-373.
Zhong, H.; Bowen, J. P. “Theoretical study of stereoselective reduction controlled by NADH analogs.” J. Mol. Graph. and Modeling 2005, 24, 1-9.
Robinson, T. R.; Hubbard, IV, R. B.; Ehlers, T.; Arbiser, J. L.; Goldsmith, D. J.; Bowen, J. P. “Synthesis and Biological Evaluation of Aromatic Enones Related to Curcumin.” Biorg. & Med. Chem. 2005, 13, 4007-4013
Zhong, H.; Stewart, E. L.; Kontoyianni, M.; Bowen, J. P. “Ab Initio and DFT Conformational Studies of Propanal, 2-Butanone, and Analogous Imines and Enamines.” J. Chem. Theory and Comput. 2005, 1, 230-238.
Chandrasekaran, V.; McGaughey, G. B.; Cavallito, C. J.; Bowen, J. P “Three-dimensional quantitative structure-activity relationship (3D-QSAR analyses of choline acetyltransferase inhibitors.” J. Mol. Graph. and Modeling 2004, 23, 69-76.
Robinson, T. R.; Ehlers, T.; Hubbard, IV, R. B.; Arbiser, J. L.; Goldsmith, D.; Bowen, J. P. “Design, Synthesis, and Biological Evaluation of Angiogenesis Inhibitors: Aromatic Enone and Dienone Analogs of Curcumin.” Biorganic & Medicinal Chemistry Letters 2003, 13, 115-117. |